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Research Article

A Precisely Regulated Gene Expression Cassette Potently Modulates Metastasis and Survival in Multiple Solid Cancers

  • Kun Yu,

    Affiliations: National Cancer Centre, Singapore, Singapore, Department of Physiology, National University of Singapore, Singapore, Singapore

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  • Kumaresan Ganesan,

    Affiliation: National Cancer Centre, Singapore, Singapore

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  • Lay Keng Tan,

    Affiliation: Duke–NUS Graduate Medical School, Singapore, Singapore

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  • Mirtha Laban,

    Affiliation: Department of Physiology, National University of Singapore, Singapore, Singapore

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  • Jeanie Wu,

    Affiliation: National Cancer Centre, Singapore, Singapore

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  • Xiao Dong Zhao,

    Affiliation: Genome Institute of Singapore, Singapore, Singapore

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  • Hongmin Li,

    Affiliation: Department of Physiology, National University of Singapore, Singapore, Singapore

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  • Carol Ho Wing Leung,

    Affiliation: Department of Physiology, National University of Singapore, Singapore, Singapore

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  • Yansong Zhu,

    Affiliation: National Cancer Centre, Singapore, Singapore

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  • Chia Lin Wei,

    Affiliation: Genome Institute of Singapore, Singapore, Singapore

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  • Shing Chuan Hooi,

    Affiliation: Department of Physiology, National University of Singapore, Singapore, Singapore

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  • Lance Miller,

    Affiliation: Genome Institute of Singapore, Singapore, Singapore

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  • Patrick Tan mail

    gmstanp@nus.edu.sg

    Affiliations: National Cancer Centre, Singapore, Singapore, Duke–NUS Graduate Medical School, Singapore, Singapore, Genome Institute of Singapore, Singapore, Singapore

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  • Published: July 18, 2008
  • DOI: 10.1371/journal.pgen.1000129

About the Authors

Kun Yu, Kumaresan Ganesan, Jeanie Wu, Yansong Zhu, Patrick Tan
National Cancer Centre, Singapore, Singapore
Kun Yu, Mirtha Laban, Hongmin Li, Carol Ho Wing Leung, Shing Chuan Hooi
Department of Physiology, National University of Singapore, Singapore, Singapore
Lay Keng Tan, Patrick Tan
Duke–NUS Graduate Medical School, Singapore, Singapore
Xiao Dong Zhao, Chia Lin Wei, Lance Miller, Patrick Tan
Genome Institute of Singapore, Singapore, Singapore

Corresponding Author

Email: gmstanp@nus.edu.sg

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KY PT. Performed the experiments: KY KG LKT ML JW XDZ HL CHWL YZ CLW SCH. Analyzed the data: KY. Contributed reagents/materials/analysis tools: LM. Wrote the paper: KY LM PT.