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Research Article

Global Mapping of DNA Methylation in Mouse Promoters Reveals Epigenetic Reprogramming of Pluripotency Genes

  • Cassandra R. Farthing equal contributor,

    equal contributor Contributed equally to this work with: Cassandra R. Farthing, Gabriella Ficz, Ray Kit Ng, Chun-Fung Chan, Simon Andrews

    Affiliation: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom

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  • Gabriella Ficz equal contributor,

    equal contributor Contributed equally to this work with: Cassandra R. Farthing, Gabriella Ficz, Ray Kit Ng, Chun-Fung Chan, Simon Andrews

    Affiliation: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom

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  • Ray Kit Ng equal contributor,

    equal contributor Contributed equally to this work with: Cassandra R. Farthing, Gabriella Ficz, Ray Kit Ng, Chun-Fung Chan, Simon Andrews

    Affiliation: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom

    X
  • Chun-Fung Chan equal contributor,

    equal contributor Contributed equally to this work with: Cassandra R. Farthing, Gabriella Ficz, Ray Kit Ng, Chun-Fung Chan, Simon Andrews

    Affiliation: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom

    Current address: CRYOLIFE, Cell Therapy Technologies Centre Limited, Siu Lek Yuen, Shatin, Hong Kong Special Administrative Region, People's Republic of China

    X
  • Simon Andrews equal contributor,

    equal contributor Contributed equally to this work with: Cassandra R. Farthing, Gabriella Ficz, Ray Kit Ng, Chun-Fung Chan, Simon Andrews

    Affiliation: Bioinformatics Group, The Babraham Institute, Cambridge, United Kingdom

    X
  • Wendy Dean,

    Affiliation: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom

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  • Myriam Hemberger,

    Affiliations: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom, Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom

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  • Wolf Reik mail

    wolf.reik@bbsrc.ac.uk

    Affiliations: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom, Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom

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  • Published: June 27, 2008
  • DOI: 10.1371/journal.pgen.1000116

About the Authors

Cassandra R. Farthing, Gabriella Ficz, Ray Kit Ng, Chun-Fung Chan, Wendy Dean, Myriam Hemberger, Wolf Reik
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom
Simon Andrews
Bioinformatics Group, The Babraham Institute, Cambridge, United Kingdom
Myriam Hemberger, Wolf Reik
Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom

Corresponding Author

Email: wolf.reik@bbsrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CF GF RN CC WD MH WR. Performed the experiments: CF GF RN CC. Analyzed the data: CF GF RN CC SA WD MH WR. Contributed reagents/materials/analysis tools: CF GF RN SA WD MH WR. Wrote the paper: CF GF RN SA WD MH WR.