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Research Article

Tracing Sub-Structure in the European American Population with PCA-Informative Markers

  • Peristera Paschou equal contributor mail,

    equal contributor Contributed equally to this work with: Peristera Paschou, Petros Drineas

    ppaschou@mbg.duth.gr

    Affiliation: Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece

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  • Petros Drineas equal contributor,

    equal contributor Contributed equally to this work with: Peristera Paschou, Petros Drineas

    Affiliation: Department of Computer Science, Rensselaer Polytechnic Institute, Troy, New York, United States of America

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  • Jamey Lewis,

    Affiliation: Department of Computer Science, Rensselaer Polytechnic Institute, Troy, New York, United States of America

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  • Caroline M. Nievergelt,

    Affiliations: Department of Molecular and Experimental Medicine, Scripps Genomic Medicine, The Scripps Research Institute, La Jolla, California, United States of America, Department of Psychiatry, University of California at San Diego, La Jolla, California, United States of America

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  • Deborah A. Nickerson,

    Affiliation: Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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  • Joshua D. Smith,

    Affiliation: Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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  • Paul M. Ridker,

    Affiliation: Center for Cardiovascular Disease Prevention, Divisions of Cardiovascular Diseases and Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Daniel I. Chasman,

    Affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Ronald M. Krauss,

    Affiliation: Children's Hospital Oakland Research Institute, Oakland, California, United States of America

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  • Elad Ziv

    Affiliations: Division of General Internal Medicine, Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America, Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

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  • Published: July 04, 2008
  • DOI: 10.1371/journal.pgen.1000114

About the Authors

Peristera Paschou
Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece
Petros Drineas, Jamey Lewis
Department of Computer Science, Rensselaer Polytechnic Institute, Troy, New York, United States of America
Caroline M. Nievergelt
Department of Molecular and Experimental Medicine, Scripps Genomic Medicine, The Scripps Research Institute, La Jolla, California, United States of America
Caroline M. Nievergelt
Department of Psychiatry, University of California at San Diego, La Jolla, California, United States of America
Deborah A. Nickerson, Joshua D. Smith
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
Paul M. Ridker
Center for Cardiovascular Disease Prevention, Divisions of Cardiovascular Diseases and Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Daniel I. Chasman
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Ronald M. Krauss
Children's Hospital Oakland Research Institute, Oakland, California, United States of America
Elad Ziv
Division of General Internal Medicine, Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
Elad Ziv
Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: ppaschou@mbg.duth.gr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PP PD EZ. Performed the experiments: PP PD JL. Analyzed the data: PP PD JL CN EZ. Contributed reagents/materials/analysis tools: PP PD DN JS PR DC RK EZ. Wrote the paper: PP PD EZ.