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Research Article

Evaluating Statistical Methods Using Plasmode Data Sets in the Age of Massive Public Databases: An Illustration Using False Discovery Rates

  • Gary L. Gadbury,

    Affiliations: Department of Statistics, Kansas State University, Manhattan, Kansas, United States of America, Department of Mathematics and Statistics, Missouri University of Science and Technology, Rolla, Missouri, United States of America, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Qinfang Xiang,

    Affiliation: Endo Pharmaceuticals, Chadds Ford, Pennsylvania, United States of America

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  • Lin Yang,

    Affiliation: Department of Mathematics and Statistics, Missouri University of Science and Technology, Rolla, Missouri, United States of America

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  • Stephen Barnes,

    Affiliations: Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Center for Nutrient–Gene Interaction, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Grier P. Page,

    Affiliation: Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • David B. Allison mail

    dallison@ms.soph.uab.edu

    Affiliations: Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    X
  • Published: June 20, 2008
  • DOI: 10.1371/journal.pgen.1000098

About the Authors

Gary L. Gadbury
Department of Statistics, Kansas State University, Manhattan, Kansas, United States of America
Gary L. Gadbury, Lin Yang
Department of Mathematics and Statistics, Missouri University of Science and Technology, Rolla, Missouri, United States of America
Gary L. Gadbury, Grier P. Page, David B. Allison
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Qinfang Xiang
Endo Pharmaceuticals, Chadds Ford, Pennsylvania, United States of America
Stephen Barnes
Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Stephen Barnes
Center for Nutrient–Gene Interaction, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
David B. Allison
Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Corresponding Author

Email: dallison@ms.soph.uab.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GG DA. Performed the experiments: QX. Analyzed the data: LY. Wrote the paper: GG SB GP DA.