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Research Article

Novel Roles for MLH3 Deficiency and TLE6-Like Amplification in DNA Mismatch Repair-Deficient Gastrointestinal Tumorigenesis and Progression

  • Peng-Chieh Chen,

    Affiliations: Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America, Department of Medicine, University of California Irvine, Irvine, California, United States of America

    Current address: Department of Genetics, Harvard Medical School, Harvard Partners Center for Genetics and Genomics, and Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Mari Kuraguchi,

    Affiliations: Department of Genetics, Harvard Medical School, Harvard Partners Center for Genetics and Genomics, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • John Velasquez,

    Affiliation: Department of Medicine, University of California Irvine, Irvine, California, United States of America

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  • Yuxun Wang,

    Affiliation: Department of Molecular Genetics, Albert Einstein College of Medicine, New York, New York, United States of America

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  • Kan Yang,

    Affiliation: Strang Cancer Research Laboratory, Department of Medicine, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Robert Edwards,

    Affiliation: Department of Pathology, University of California Irvine, Irvine, California, United States of America

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  • Dan Gillen,

    Affiliation: Department of Statistics, University of California Irvine, Irvine, California, United States of America

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  • Winfried Edelmann,

    Affiliation: Department of Molecular Genetics, Albert Einstein College of Medicine, New York, New York, United States of America

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  • Raju Kucherlapati,

    Affiliations: Department of Genetics, Harvard Medical School, Harvard Partners Center for Genetics and Genomics, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Steven M. Lipkin mail

    slipkin@uci.edu

    Affiliations: Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America, Department of Medicine, University of California Irvine, Irvine, California, United States of America

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  • Published: June 13, 2008
  • DOI: 10.1371/journal.pgen.1000092

About the Authors

Peng-Chieh Chen, Steven M. Lipkin
Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America
Peng-Chieh Chen, John Velasquez, Steven M. Lipkin
Department of Medicine, University of California Irvine, Irvine, California, United States of America
Mari Kuraguchi, Raju Kucherlapati
Department of Genetics, Harvard Medical School, Harvard Partners Center for Genetics and Genomics, Boston, Massachusetts, United States of America
Mari Kuraguchi, Raju Kucherlapati
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Yuxun Wang, Winfried Edelmann
Department of Molecular Genetics, Albert Einstein College of Medicine, New York, New York, United States of America
Kan Yang
Strang Cancer Research Laboratory, Department of Medicine, Weill Medical College of Cornell University, New York, New York, United States of America
Robert Edwards
Department of Pathology, University of California Irvine, Irvine, California, United States of America
Dan Gillen
Department of Statistics, University of California Irvine, Irvine, California, United States of America

Corresponding Author

Email: slipkin@uci.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PC RK SL. Performed the experiments: PC MK. Analyzed the data: PC MK KY RE DG SL. Contributed reagents/materials/analysis tools: PC JV YW WE RK SL. Wrote the paper: PC SL.