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Research Article

An Inducible and Reversible Mouse Genetic Rescue System

  • Hongkui Zeng equal contributor,

    equal contributor Contributed equally to this work with: Hongkui Zeng, Kyoji Horie

    Affiliation: Omeros Corporation, Seattle, Washington, United States of America

    Current address: Allen Institute for Brain Science, Seattle, Washington, United States of America;

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  • Kyoji Horie equal contributor,

    equal contributor Contributed equally to this work with: Hongkui Zeng, Kyoji Horie

    Affiliation: Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland, United States of America

    Current address: Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

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  • Linda Madisen,

    Affiliation: Omeros Corporation, Seattle, Washington, United States of America

    Current address: Allen Institute for Brain Science, Seattle, Washington, United States of America;

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  • Maria N. Pavlova,

    Affiliation: Omeros Corporation, Seattle, Washington, United States of America

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  • Galina Gragerova,

    Affiliation: Omeros Corporation, Seattle, Washington, United States of America

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  • Alex D. Rohde,

    Affiliation: Omeros Corporation, Seattle, Washington, United States of America

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  • Brian A. Schimpf,

    Affiliation: Omeros Corporation, Seattle, Washington, United States of America

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  • Yuqiong Liang,

    Affiliation: Omeros Corporation, Seattle, Washington, United States of America

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  • Ethan Ojala,

    Affiliation: Omeros Corporation, Seattle, Washington, United States of America

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  • Farah Kramer,

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

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  • Patricia Roth,

    Affiliation: Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland, United States of America

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  • Olga Slobodskaya,

    Affiliation: Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland, United States of America

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  • Io Dolka,

    Affiliation: Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland, United States of America

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  • Eileen A. Southon,

    Affiliation: Neural Development Section, Mouse Cancer Genetics Program, National Cancer Institute-Frederick, Frederick, Maryland, United States of America

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  • Lino Tessarollo,

    Affiliation: Neural Development Section, Mouse Cancer Genetics Program, National Cancer Institute-Frederick, Frederick, Maryland, United States of America

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  • Karin E. Bornfeldt,

    Affiliation: Department of Pathology, University of Washington, Seattle, Washington, United States of America

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  • Alexander Gragerov,

    Affiliation: Omeros Corporation, Seattle, Washington, United States of America

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  • George N. Pavlakis mail,

    ggaitanaris@omeros.com (GGA); pavlakis@ncifcrf.gov (GNP)

    Affiliation: Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland, United States of America

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  • George A. Gaitanaris mail

    ggaitanaris@omeros.com (GGA); pavlakis@ncifcrf.gov (GNP)

    Affiliation: Omeros Corporation, Seattle, Washington, United States of America

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  • Published: May 09, 2008
  • DOI: 10.1371/journal.pgen.1000069

About the Authors

Hongkui Zeng, Linda Madisen, Maria N. Pavlova, Galina Gragerova, Alex D. Rohde, Brian A. Schimpf, Yuqiong Liang, Ethan Ojala, Alexander Gragerov, George A. Gaitanaris
Omeros Corporation, Seattle, Washington, United States of America
Kyoji Horie, Patricia Roth, Olga Slobodskaya, Io Dolka, George N. Pavlakis
Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland, United States of America
Farah Kramer, Karin E. Bornfeldt
Department of Pathology, University of Washington, Seattle, Washington, United States of America
Eileen A. Southon, Lino Tessarollo
Neural Development Section, Mouse Cancer Genetics Program, National Cancer Institute-Frederick, Frederick, Maryland, United States of America

Corresponding Authors

Competing Interests

Authors currently affiliated with Omeros Corporation wish to declare potential financial interests.

Author Contributions

Conceived and designed the experiments: HZ KH LM LT KB GP GAG. Performed the experiments: HZ KH LM MP GG AR BS YL EO FK PR OS ID ES AG. Analyzed the data: HZ KH KB AG GAG. Contributed reagents/materials/analysis tools: FK ES LT GP. Wrote the paper: HZ KH GAG.