Advertisement
Research Article

A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels

  • Trevor C. Y. Kwok equal contributor,

    equal contributor Contributed equally to this work with: Trevor C. Y. Kwok, Kwokyin Hui

    Affiliation: Department of Molecular Genetics, The Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

    X
  • Kwokyin Hui equal contributor,

    equal contributor Contributed equally to this work with: Trevor C. Y. Kwok, Kwokyin Hui

    Affiliation: Department of Physiology, University of Toronto, Toronto, Ontario, Canada

    X
  • Wojciech Kostelecki,

    Affiliation: Department of Physiology, University of Toronto, Toronto, Ontario, Canada

    X
  • Nicole Ricker,

    Affiliation: Department of Molecular Genetics, The Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

    X
  • Guillermo Selman,

    Affiliation: Department of Molecular Genetics, The Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

    X
  • Zhong-Ping Feng mail,

    zp.feng@utoronto.ca (ZPF); peter.roy@utoronto.ca (PJR)

    Affiliation: Department of Physiology, University of Toronto, Toronto, Ontario, Canada

    X
  • Peter John Roy mail

    zp.feng@utoronto.ca (ZPF); peter.roy@utoronto.ca (PJR)

    Affiliation: Department of Molecular Genetics, The Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

    X
  • Published: May 09, 2008
  • DOI: 10.1371/journal.pgen.1000067

About the Authors

Trevor C. Y. Kwok, Nicole Ricker, Guillermo Selman, Peter John Roy
Department of Molecular Genetics, The Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
Kwokyin Hui, Wojciech Kostelecki, Zhong-Ping Feng
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TK KH PR. Performed the experiments: TK KH WK NR GS ZF. Analyzed the data: TK KH PR. Wrote the paper: TK KH PR.