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Research Article

Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus

  • Natalie D. Fedorova,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Nora Khaldi,

    Affiliation: Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin, Ireland

    X
  • Vinita S. Joardar,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Rama Maiti,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Paolo Amedeo,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Michael J. Anderson,

    Affiliation: School of Medicine and Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

    X
  • Jonathan Crabtree,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Joana C. Silva,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Jonathan H. Badger,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Ahmed Albarraq,

    Affiliation: School of Medicine and Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

    X
  • Sam Angiuoli,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Howard Bussey,

    Affiliation: Department of Biology, McGill University, Montreal, Quebec, Canada

    X
  • Paul Bowyer,

    Affiliation: School of Medicine and Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

    X
  • Peter J. Cotty,

    Affiliation: Agricultural Research Service, United States Department of Agriculture, Department of Plant Sciences, University of Arizona, Tucson, Arizona, United States of America

    X
  • Paul S. Dyer,

    Affiliation: School of Biology, University of Nottingham, Nottingham, United Kingdom

    X
  • Amy Egan,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Kevin Galens,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Claire M. Fraser-Liggett,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Brian J. Haas,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Jason M. Inman,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Richard Kent,

    Affiliation: School of Medicine and Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

    X
  • Sebastien Lemieux,

    Affiliation: Institute for Research in Immunology and Cancer, Department of Computer Science and Operations Research, Universite de Montreal, Montreal, Canada

    X
  • Iran Malavazi,

    Affiliation: Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil

    X
  • Joshua Orvis,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Terry Roemer,

    Affiliation: Merck & Co., Inc., Whitehouse Station, New Jersey, United States of America

    X
  • Catherine M. Ronning,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Jaideep P. Sundaram,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Granger Sutton,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Geoff Turner,

    Affiliation: Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield, United Kingdom

    X
  • J. Craig Venter,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Owen R. White,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Brett R. Whitty,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Phil Youngman,

    Affiliation: Merck & Co., Inc., Whitehouse Station, New Jersey, United States of America

    X
  • Kenneth H. Wolfe,

    Affiliation: Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin, Ireland

    X
  • Gustavo H. Goldman,

    Affiliation: Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil

    X
  • Jennifer R. Wortman,

    Affiliation: The J. Craig Venter Institute, Rockville, Maryland, United States of America

    X
  • Bo Jiang,

    Affiliation: Merck & Co., Inc., Whitehouse Station, New Jersey, United States of America

    X
  • David W. Denning,

    Affiliation: School of Medicine and Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

    X
  • William C. Nierman mail

    wnierman@jcvi.org

    Affiliations: The J. Craig Venter Institute, Rockville, Maryland, United States of America, Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington DC, United States of America

    X
  • Published: April 11, 2008
  • DOI: 10.1371/journal.pgen.1000046

About the Authors

Natalie D. Fedorova, Vinita S. Joardar, Rama Maiti, Paolo Amedeo, Jonathan Crabtree, Joana C. Silva, Jonathan H. Badger, Sam Angiuoli, Amy Egan, Kevin Galens, Claire M. Fraser-Liggett, Brian J. Haas, Jason M. Inman, Joshua Orvis, Catherine M. Ronning, Jaideep P. Sundaram, Granger Sutton, J. Craig Venter, Owen R. White, Brett R. Whitty, Jennifer R. Wortman, William C. Nierman
The J. Craig Venter Institute, Rockville, Maryland, United States of America
Nora Khaldi, Kenneth H. Wolfe
Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin, Ireland
Michael J. Anderson, Ahmed Albarraq, Paul Bowyer, Richard Kent, David W. Denning
School of Medicine and Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
Howard Bussey
Department of Biology, McGill University, Montreal, Quebec, Canada
Peter J. Cotty
Agricultural Research Service, United States Department of Agriculture, Department of Plant Sciences, University of Arizona, Tucson, Arizona, United States of America
Paul S. Dyer
School of Biology, University of Nottingham, Nottingham, United Kingdom
Sebastien Lemieux
Institute for Research in Immunology and Cancer, Department of Computer Science and Operations Research, Universite de Montreal, Montreal, Canada
Iran Malavazi, Gustavo H. Goldman
Departamento de Ciencias Farmaceuticas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
Terry Roemer, Phil Youngman, Bo Jiang
Merck & Co., Inc., Whitehouse Station, New Jersey, United States of America
Geoff Turner
Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield, United Kingdom
William C. Nierman
Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington DC, United States of America

Corresponding Author

Email: wnierman@jcvi.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DD WN. Performed the experiments: MA AA HB PC RK IM. Analyzed the data: NF NK VJ RM PA MA JC JS JB SA PB PC PD AE KG BH JI SL JO TR CR JS GS GT BW PY KW GG JW BJ DD. Contributed reagents/materials/analysis tools: JC JS JB SA AE CF BH JO GS JV OW. Wrote the paper: NF NK DD WN.