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Research Article

A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci

  • Ying Liu,

    Affiliation: Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Cynthia Helms,

    Affiliation: Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Wilson Liao,

    Affiliation: Cardiovascular Research Institute and Center for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Lisa C. Zaba,

    Affiliation: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America

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  • Shenghui Duan,

    Affiliation: Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Jennifer Gardner,

    Affiliation: Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Carol Wise,

    Affiliation: Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, Texas, United States of America

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  • Andrew Miner,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • M. J. Malloy,

    Affiliation: Cardiovascular Research Institute and Center for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Clive R. Pullinger,

    Affiliation: Cardiovascular Research Institute and Center for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • John P. Kane,

    Affiliation: Cardiovascular Research Institute and Center for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Scott Saccone,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Jane Worthington,

    Affiliation: Arc Epidemiology Research Unit, University of Manchester, Manchester, United Kingdom

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  • Ian Bruce,

    Affiliation: Arc Epidemiology Research Unit, University of Manchester, Manchester, United Kingdom

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  • Pui–Yan Kwok,

    Affiliation: Cardiovascular Research Institute and Center for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Alan Menter,

    Affiliation: Department of Internal Medicine, Division of Dermatology, Baylor University Medical Center, Dallas, Texas, United States of America

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  • James Krueger,

    Affiliation: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America

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  • Anne Barton,

    Affiliation: Arc Epidemiology Research Unit, University of Manchester, Manchester, United Kingdom

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  • Nancy L. Saccone,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Anne M. Bowcock mail

    bowcock@genetics.wustl.edu

    Affiliation: Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Published: April 04, 2008
  • DOI: 10.1371/journal.pgen.1000041

About the Authors

Ying Liu, Cynthia Helms, Shenghui Duan, Jennifer Gardner, Anne M. Bowcock
Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
Wilson Liao, M. J. Malloy, Clive R. Pullinger, John P. Kane, Pui–Yan Kwok
Cardiovascular Research Institute and Center for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
Lisa C. Zaba, James Krueger
Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America
Carol Wise
Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, Texas, United States of America
Andrew Miner, Scott Saccone, Nancy L. Saccone
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America
Jane Worthington, Ian Bruce, Anne Barton
Arc Epidemiology Research Unit, University of Manchester, Manchester, United Kingdom
Alan Menter
Department of Internal Medicine, Division of Dermatology, Baylor University Medical Center, Dallas, Texas, United States of America

Corresponding Author

Email: bowcock@genetics.wustl.edu

Competing Interests

Patent application on findings in process.

Author Contributions

Conceived and designed the experiments: A. Bowcock. Performed the experiments: L. Zaba, S. Duan. Analyzed the data: Y. Liu, C. Helms, J. Kane, N. Saccone. Contributed reagents/materials/analysis tools: W. Liao, J. Gardner, C. Wise, A. Miner, M. Malloy, C. Pullinger, J. Kane, J. Worthington, I. Bruce, P. Kwok, A. Menter, A. Barton. Wrote the paper: A. Bowcock. Prepared figures: S. Saccone. Revised the manuscript: A. Bowcock.