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Research Article

Recruitment to the Nuclear Periphery Can Alter Expression of Genes in Human Cells

  • Lee E. Finlan,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Duncan Sproul,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Inga Thomson,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Shelagh Boyle,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Elizabeth Kerr,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Paul Perry,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Bauke Ylstra,

    Affiliation: Micro Array Facility, VUMC Cancer Center Amsterdam, Amsterdam, The Netherlands

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  • Jonathan R. Chubb,

    Affiliation: Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Wendy A. Bickmore mail

    W.Bickmore@hgu.mrc.ac.uk

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: March 21, 2008
  • DOI: 10.1371/journal.pgen.1000039

About the Authors

Lee E. Finlan, Duncan Sproul, Inga Thomson, Shelagh Boyle, Elizabeth Kerr, Paul Perry, Wendy A. Bickmore
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Bauke Ylstra
Micro Array Facility, VUMC Cancer Center Amsterdam, Amsterdam, The Netherlands
Jonathan R. Chubb
Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom

Corresponding Author

Email: W.Bickmore@hgu.mrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LF WB. Performed the experiments: LF SB EK. Analyzed the data: LF DS WB. Contributed reagents/materials/analysis tools: LF IT PP BY JC WB. Wrote the paper: LF WB.