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Research Article

Differential Allelic Expression in the Human Genome: A Robust Approach To Identify Genetic and Epigenetic Cis-Acting Mechanisms Regulating Gene Expression

  • David Serre mail,

    serred@ccf.org

    Affiliations: McGill University, Montreal, Quebec, Canada, Genome Quebec Innovation Centre, Montreal, Quebec, Canada

    Current address: Genomic Medicine Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

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  • Scott Gurd,

    Affiliation: McGill University, Montreal, Quebec, Canada

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  • Bing Ge,

    Affiliations: McGill University, Montreal, Quebec, Canada, Genome Quebec Innovation Centre, Montreal, Quebec, Canada

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  • Robert Sladek,

    Affiliation: McGill University, Montreal, Quebec, Canada

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  • Donna Sinnett,

    Affiliations: McGill University, Montreal, Quebec, Canada, Genome Quebec Innovation Centre, Montreal, Quebec, Canada

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  • Eef Harmsen,

    Affiliations: McGill University, Montreal, Quebec, Canada, Genome Quebec Innovation Centre, Montreal, Quebec, Canada

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  • Marina Bibikova,

    Affiliation: Illumina Inc., San Diego, California, United States of America

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  • Eugene Chudin,

    Affiliation: Illumina Inc., San Diego, California, United States of America

    Current address: Merck & Co. Inc., Seattle, Washington, United States of America

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  • David L. Barker,

    Affiliation: Illumina Inc., San Diego, California, United States of America

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  • Todd Dickinson,

    Affiliation: Illumina Inc., San Diego, California, United States of America

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  • Jian-Bing Fan,

    Affiliation: Illumina Inc., San Diego, California, United States of America

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  • Thomas J. Hudson

    Affiliations: McGill University, Montreal, Quebec, Canada, Genome Quebec Innovation Centre, Montreal, Quebec, Canada

    Current address: Ontario Institute for Cancer Research, Toronto, Ontario, Canada

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  • Published: February 29, 2008
  • DOI: 10.1371/journal.pgen.1000006

About the Authors

David Serre, Scott Gurd, Bing Ge, Robert Sladek, Donna Sinnett, Eef Harmsen, Thomas J. Hudson
McGill University, Montreal, Quebec, Canada
David Serre, Bing Ge, Donna Sinnett, Eef Harmsen, Thomas J. Hudson
Genome Quebec Innovation Centre, Montreal, Quebec, Canada
Marina Bibikova, Eugene Chudin, David L. Barker, Todd Dickinson, Jian-Bing Fan
Illumina Inc., San Diego, California, United States of America

Corresponding Author

Email: serred@ccf.org

Competing Interests

MB, DLB, TD, and J-BF are employed by the company that makes the array chips analyzed. EC is a former employee.

Author Contributions

Conceived and designed the experiments: DS JF TH. Performed the experiments: SG DS. Analyzed the data: DS SG BG RS TH. Contributed reagents/materials/analysis tools: DS MB EC DB TD JF TH. Wrote the paper: DS RS EH JF TH.