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Research Article

The Secreted Metalloprotease ADAMTS20 Is Required for Melanoblast Survival

  • Debra L. Silver,

    Affiliation: Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America

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  • Ling Hou,

    Affiliation: Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America

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  • Robert Somerville,

    Affiliation: Department of Biomedical Engineering, Cleveland Clinic Foundation-ND20, Cleveland, Ohio, United States of America

    Current address: Alba Therapeutics, Baltimore, Maryland, United States of America

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  • Mary E. Young,

    Affiliation: Department of Biomedical Engineering, Cleveland Clinic Foundation-ND20, Cleveland, Ohio, United States of America

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  • Suneel S. Apte,

    Affiliation: Department of Biomedical Engineering, Cleveland Clinic Foundation-ND20, Cleveland, Ohio, United States of America

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  • William J. Pavan mail

    bpavan@mail.nih.gov

    Affiliation: Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America

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  • Published: February 29, 2008
  • DOI: 10.1371/journal.pgen.1000003

About the Authors

Debra L. Silver, Ling Hou, William J. Pavan
Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
Robert Somerville, Mary E. Young, Suneel S. Apte
Department of Biomedical Engineering, Cleveland Clinic Foundation-ND20, Cleveland, Ohio, United States of America

Corresponding Author

Email: bpavan@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DS SA WP. Performed the experiments: DS LH RS MY. Analyzed the data: DS LH RS MY SA WP. Contributed reagents/materials/analysis tools: DS LH RS MY WP. Wrote the paper: DS SA WP.