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Research Article

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

  • Min Wei equal contributor,

    equal contributor Contributed equally to this work with: Min Wei, Paola Fabrizio

    Affiliations: Andrus Gerontology Center, University of Southern California, Los Angeles, California, United States of America, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America

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  • Paola Fabrizio equal contributor,

    equal contributor Contributed equally to this work with: Min Wei, Paola Fabrizio

    Affiliations: Andrus Gerontology Center, University of Southern California, Los Angeles, California, United States of America, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America

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  • Jia Hu,

    Affiliation: Andrus Gerontology Center, University of Southern California, Los Angeles, California, United States of America

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  • Huanying Ge,

    Affiliation: Department of Computational and Molecular Biology, University of Southern California, Los Angeles, California, United States of America

    X
  • Chao Cheng,

    Affiliation: Department of Computational and Molecular Biology, University of Southern California, Los Angeles, California, United States of America

    X
  • Lei Li,

    Affiliation: Department of Computational and Molecular Biology, University of Southern California, Los Angeles, California, United States of America

    X
  • Valter D Longo mail

    To whom correspondence should be addressed. E-mail: vlongo@usc.edu

    Affiliations: Andrus Gerontology Center, University of Southern California, Los Angeles, California, United States of America, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America

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  • Published: January 25, 2008
  • DOI: 10.1371/journal.pgen.0040013

About the Authors

Min Wei, Paola Fabrizio, Jia Hu, Valter D Longo
Andrus Gerontology Center, University of Southern California, Los Angeles, California, United States of America
Min Wei, Paola Fabrizio, Valter D Longo
Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America
Huanying Ge, Chao Cheng, Lei Li
Department of Computational and Molecular Biology, University of Southern California, Los Angeles, California, United States of America

Corresponding Author

Email: vlongo@usc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MW, PF, and VDL conceived and designed the experiments and wrote the paper. MW, PF, JH, and VDL performed the experiments. MW, PF, JH, HG, CC, LL, and VDL analyzed the data. LL and VDL contributed reagents/materials/analysis tools.