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Research Article

Analysis and Application of European Genetic Substructure Using 300 K SNP Information

  • Chao Tian,

    Affiliations: Rowe Program in Human Genetics, University of California Davis, Davis, California, United States of America, Department of Biochemistry, University of California Davis, Davis, California, United States of America, Department of Medicine, University of California Davis, Davis, California, United States of America

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  • Robert M Plenge,

    Affiliations: Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Division of Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Michael Ransom,

    Affiliations: Rowe Program in Human Genetics, University of California Davis, Davis, California, United States of America, Department of Biochemistry, University of California Davis, Davis, California, United States of America, Department of Medicine, University of California Davis, Davis, California, United States of America

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  • Annette Lee,

    Affiliation: The Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York, United States of America

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  • Pablo Villoslada,

    Affiliation: Center for Applied Medical Research, University of Navarra, Pamplona, Spain

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  • Carlo Selmi,

    Affiliations: Department of Medicine, University of California Davis, Davis, California, United States of America, Division of Internal Medicine, San Paolo Hospital School of Medicine, University of Milan, Milan, Italy

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  • Lars Klareskog,

    Affiliation: Karolinska University Hospital, Stockholm, Sweden

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  • Ann E Pulver,

    Affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

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  • Lihong Qi,

    Affiliations: Rowe Program in Human Genetics, University of California Davis, Davis, California, United States of America, Department of Public Health Sciences, University of California Davis, Davis, California, United States of America

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  • Peter K Gregersen,

    Affiliation: The Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York, United States of America

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  • Michael F Seldin mail

    To whom correspondence should be addressed. E-mail: mfseldin@ucdavis.edu

    Affiliations: Rowe Program in Human Genetics, University of California Davis, Davis, California, United States of America, Department of Biochemistry, University of California Davis, Davis, California, United States of America, Department of Medicine, University of California Davis, Davis, California, United States of America

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  • Published: January 18, 2008
  • DOI: 10.1371/journal.pgen.0040004

About the Authors

Chao Tian, Michael Ransom, Lihong Qi, Michael F Seldin
Rowe Program in Human Genetics, University of California Davis, Davis, California, United States of America
Chao Tian, Michael Ransom, Michael F Seldin
Department of Biochemistry, University of California Davis, Davis, California, United States of America
Chao Tian, Michael Ransom, Carlo Selmi, Michael F Seldin
Department of Medicine, University of California Davis, Davis, California, United States of America
Robert M Plenge
Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Robert M Plenge
Division of Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Annette Lee, Peter K Gregersen
The Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York, United States of America
Pablo Villoslada
Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Carlo Selmi
Division of Internal Medicine, San Paolo Hospital School of Medicine, University of Milan, Milan, Italy
Lars Klareskog
Karolinska University Hospital, Stockholm, Sweden
Ann E Pulver
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
Lihong Qi
Department of Public Health Sciences, University of California Davis, Davis, California, United States of America

Corresponding Author

Email: mfseldin@ucdavis.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The study was conceived by CT and MFS and designed by CT, RMP, PKG, and MFS. RMP, AL, PV, CS, LK, AEP, PKG, and MFS recruited individuals and obtained and prepared DNA samples used in these studies. Analyses were performed by CT, RMP, MR, LQ, PKG, and MFS. The manuscript was written by CT and MFS with contributions from RMP, PV, CS, LK, and PKG.