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Research Article

Deletion of the MBII-85 snoRNA Gene Cluster in Mice Results in Postnatal Growth Retardation

  • Boris V Skryabin,

    Affiliation: Institute of Experimental Pathology (ZMBE), University of Münster, Münster, Germany

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  • Leonid V Gubar,

    Affiliation: Institute of Experimental Pathology (ZMBE), University of Münster, Münster, Germany

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  • Birte Seeger,

    Affiliation: Institute of Experimental Pathology (ZMBE), University of Münster, Münster, Germany

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  • Jana Pfeiffer,

    Affiliation: Institute of Experimental Pathology (ZMBE), University of Münster, Münster, Germany

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  • Sergej Handel,

    Affiliation: Institute of Experimental Pathology (ZMBE), University of Münster, Münster, Germany

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  • Thomas Robeck

    Affiliation: Institute of Experimental Pathology (ZMBE), University of Münster, Münster, Germany

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  • Published: December 28, 2007
  • DOI: 10.1371/journal.pgen.0030235

About the Authors

Boris V Skryabin, Leonid V Gubar, Birte Seeger, Jana Pfeiffer, Sergej Handel, Thomas Robeck
Institute of Experimental Pathology (ZMBE), University of Münster, Münster, Germany

Corresponding Author

Email: RNA.world@uni-muenster.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

BVS generated the PWScr-deleted mice and participated in manuscript preparation. LVG performed Southern blot analyses of mouse tail biopsies. BS performed Northern blot analyses. JP assisted with ES cell culture. SH assisted with blastocyst injection. EK isolated PAC clones. TR assisted with mouse weight analysis. TSR participated in result interpretation and manuscript writing. JB conceived and supervised the project and participated in manuscript preparation.