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Research Article

Distinct Roles and Regulations for Hoxd Genes in Metanephric Kidney Development

  • Nicolas Di-Poï,

    Affiliation: Department of Zoology and Animal Biology, University of Geneva, Geneva, Swizerland

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  • József Zákány,

    Affiliation: Department of Zoology and Animal Biology, University of Geneva, Geneva, Swizerland

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  • Denis Duboule mail

    To whom correspondence should be addressed. E-mail: denis.duboule@zoo.unige.ch

    Affiliations: Department of Zoology and Animal Biology, University of Geneva, Geneva, Swizerland, School of Life Sciences, Ecole Polytechnique Fédérale Lausanne, Lausanne, Switzerland

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  • Published: December 21, 2007
  • DOI: 10.1371/journal.pgen.0030232

About the Authors

Nicolas Di-Poï, József Zákány, Denis Duboule
Department of Zoology and Animal Biology, University of Geneva, Geneva, Swizerland
Denis Duboule
School of Life Sciences, Ecole Polytechnique Fédérale Lausanne, Lausanne, Switzerland

Corresponding Author

Email: denis.duboule@zoo.unige.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

NDP, JZ, and DD conceived and designed the experiments and analyzed the data. NDP performed the experiments. JZ isolated the novel recombinant alleles and identified the homozygous Del(4–11) kidney hypoplasia phenotype. NDP and DD wrote the paper.