Advertisement
Research Article

Excess Single-Stranded DNA Inhibits Meiotic Double-Strand Break Repair

  • Rebecca Johnson equal contributor,

    equal contributor Contributed equally to this work with: Rebecca Johnson, Valérie Borde, Matthew J Neale

    Affiliation: Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom

    ¤a Current address: Helen L. and Martin S. Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine and Department of Pathology, New York University School of Medicine, New York, New York, United States of America

    X
  • Valérie Borde equal contributor,

    equal contributor Contributed equally to this work with: Rebecca Johnson, Valérie Borde, Matthew J Neale

    Affiliation: Institut Curie, Centre de Recherche, Recombinaison et Instabilite Genetique UMR7147 CNRS Université P. et M. Curie, Paris, France

    X
  • Matthew J Neale equal contributor,

    equal contributor Contributed equally to this work with: Rebecca Johnson, Valérie Borde, Matthew J Neale

    Affiliation: Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom

    ¤b Current address: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

    X
  • Anna Bishop-Bailey,

    Affiliation: Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom

    X
  • Matthew North,

    Affiliation: Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom

    ¤c Current address: Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California, United States of America

    X
  • Sheila Harris,

    Affiliation: Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom

    ¤d Current address: Tumour Microcirculation Group, Royal Hallamshire Hospital, University of Sheffield, Sheffield, United Kingdom

    X
  • Alain Nicolas,

    Affiliation: Institut Curie, Centre de Recherche, Recombinaison et Instabilite Genetique UMR7147 CNRS Université P. et M. Curie, Paris, France

    X
  • Alastair S. H Goldman mail

    To whom correspondence should be addressed. E-mail: a.goldman@shef.ac.uk

    Affiliation: Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom

    X
  • Published: November 30, 2007
  • DOI: 10.1371/journal.pgen.0030223

About the Authors

Rebecca Johnson, Matthew J Neale, Anna Bishop-Bailey, Matthew North, Sheila Harris, Alastair S. H Goldman
Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom
Valérie Borde, Alain Nicolas
Institut Curie, Centre de Recherche, Recombinaison et Instabilite Genetique UMR7147 CNRS Université P. et M. Curie, Paris, France

Corresponding Author

Email: a.goldman@shef.ac.uk

Author Contributions

ASHG conceived and designed the experiments. RJ, VB, MJN, AB-B, and MN performed the experiments. SH performed the preliminary ChIP experiments. RJ, VB, MJN, AB-B, MN, and ASHG analyzed the data. AN contributed reagents/materials/analysis tools. ASHG wrote the paper with contributions from RJ, VB, MJN, and AN.