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Research Article

Genome-Wide Profiling of DNA Methylation Reveals a Class of Normally Methylated CpG Island Promoters

  • Lanlan Shen mail,

    To whom correspondence should be addressed. E-mail: lshen@mdanderson.org

    Affiliation: Department of Leukemia, The University of Texas at M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Yutaka Kondo,

    Affiliation: Aichi Cancer Center, Division of Molecular Oncology, Chikusa-Ku, Nagoya, Japan

    X
  • Yi Guo,

    Affiliation: Department of Leukemia, The University of Texas at M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Jiexin Zhang,

    Affiliation: Biostatistics and Applied Biomathematics, The University of Texas at M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Li Zhang,

    Affiliation: Biostatistics and Applied Biomathematics, The University of Texas at M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Saira Ahmed,

    Affiliation: Department of Leukemia, The University of Texas at M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Jingmin Shu,

    Affiliation: Department of Leukemia, The University of Texas at M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Xinli Chen,

    Affiliation: Department of Leukemia, The University of Texas at M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Robert A Waterland,

    Affiliation: Department of Pediatrics, Baylor College of Medicine, USDA Children's Nutrition Research Center, Houston, Texas, United States of America

    X
  • Jean-Pierre J Issa

    Affiliation: Department of Leukemia, The University of Texas at M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Published: October 26, 2007
  • DOI: 10.1371/journal.pgen.0030181

About the Authors

Lanlan Shen, Yi Guo, Saira Ahmed, Jingmin Shu, Xinli Chen, Jean-Pierre J Issa
Department of Leukemia, The University of Texas at M. D. Anderson Cancer Center, Houston, Texas, United States of America
Yutaka Kondo
Aichi Cancer Center, Division of Molecular Oncology, Chikusa-Ku, Nagoya, Japan
Jiexin Zhang, Li Zhang
Biostatistics and Applied Biomathematics, The University of Texas at M. D. Anderson Cancer Center, Houston, Texas, United States of America
Robert A Waterland
Department of Pediatrics, Baylor College of Medicine, USDA Children's Nutrition Research Center, Houston, Texas, United States of America

Corresponding Author

Email: lshen@mdanderson.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LS and JPJI designed the research; LS, YK, YG, SA, JS, XC, and RAW performed the research; JZ and LZ analyzed data; and LS, RAW and JPJI wrote the paper.