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Research Article

Ancient Exaptation of a CORE-SINE Retroposon into a Highly Conserved Mammalian Neuronal Enhancer of the Proopiomelanocortin Gene

  • Andrea M Santangelo equal contributor,

    equal contributor Contributed equally to this work with: Andrea M Santangelo, Flávio S. J de Souza, Lucía F Franchini

    Affiliation: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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  • Flávio S. J de Souza equal contributor,

    equal contributor Contributed equally to this work with: Andrea M Santangelo, Flávio S. J de Souza, Lucía F Franchini

    Affiliation: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

    X
  • Lucía F Franchini equal contributor,

    equal contributor Contributed equally to this work with: Andrea M Santangelo, Flávio S. J de Souza, Lucía F Franchini

    Affiliation: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

    X
  • Viviana F Bumaschny,

    Affiliation: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

    X
  • Malcolm J Low,

    Affiliations: Center for the Study of Weight Regulation and Associated Disorders, Portland, Oregon, United States of America, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, United States of America

    X
  • Marcelo Rubinstein mail

    To whom correspondence should be addressed. E-mail: mrubins@dna.uba.ar

    Affiliations: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina, Center for the Study of Weight Regulation and Associated Disorders, Portland, Oregon, United States of America, Departmento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina, Centro de Estudios Científicos, Valdivia, Chile

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  • Published: October 05, 2007
  • DOI: 10.1371/journal.pgen.0030166

About the Authors

Andrea M Santangelo, Flávio S. J de Souza, Lucía F Franchini, Viviana F Bumaschny, Marcelo Rubinstein
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
Malcolm J Low, Marcelo Rubinstein
Center for the Study of Weight Regulation and Associated Disorders, Portland, Oregon, United States of America
Malcolm J Low
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, United States of America
Marcelo Rubinstein
Departmento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Marcelo Rubinstein
Centro de Estudios Científicos, Valdivia, Chile

Corresponding Author

Email: mrubins@dna.uba.ar

Competing Interests

FSJdS, MJL, and MR have intellectual property and patent interests in the POMC neuronal-specific enhancers and have received income from the licensing of this intellectual property and related research material to financially interested companies.

Author Contributions

AMS, FSJdS, LFF, MJL, and MR conceived and designed the experiments and analyzed the data. AMS, FSJdS, LFF, and VFB performed the experiments. LFF, MJL, and MR contributed reagents/materials/analysis tools. FSJdS, LFF, and MR wrote the paper. MJL revised the manuscript.