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Research Article

Capturing Heterogeneity in Gene Expression Studies by Surrogate Variable Analysis

  • Jeffrey T Leek,

    Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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  • John D Storey mail

    To whom correspondence should be addressed. E-mail: jstorey@u.washington.edu

    Affiliations: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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  • Published: September 28, 2007
  • DOI: 10.1371/journal.pgen.0030161

About the Authors

Jeffrey T Leek, John D Storey
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
John D Storey
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: jstorey@u.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JTL and JDS conceived and designed the experiments, performed the experiments, contributed reagents/materials/analysis tools, and wrote the paper. JTL analyzed the data.