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Research Article

PCA-Correlated SNPs for Structure Identification in Worldwide Human Populations

  • Peristera Paschou mail,

    To whom correspondence should be addressed. E-mail: ppaschou@mbg.duth.gr

    Affiliation: Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece

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  • Elad Ziv,

    Affiliations: Division of General Internal Medicine, University of California San Francisco, San Francisco, California, United States of America, Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America, Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

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  • Esteban G Burchard,

    Affiliations: Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, United States of America, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Shweta Choudhry,

    Affiliation: Lung Biology Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • William Rodriguez-Cintron,

    Affiliation: Pulmonary/CCM Veterans Caribbean Healthcare System, University of Puerto Rico School of Medicine, San Juan, Puerto Rico, United States of America

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  • Michael W Mahoney,

    Affiliation: Yahoo Research, Sunnyvale, California, United States of America

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  • Petros Drineas

    Affiliation: Department of Computer Science, Rensselaer Polytechnic Institute, Troy, New York, United States of America

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  • Published: September 21, 2007
  • DOI: 10.1371/journal.pgen.0030160

About the Authors

Peristera Paschou
Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece
Elad Ziv
Division of General Internal Medicine, University of California San Francisco, San Francisco, California, United States of America
Elad Ziv
Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
Elad Ziv
Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America
Esteban G Burchard
Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California, United States of America
Esteban G Burchard
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Shweta Choudhry
Lung Biology Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
William Rodriguez-Cintron
Pulmonary/CCM Veterans Caribbean Healthcare System, University of Puerto Rico School of Medicine, San Juan, Puerto Rico, United States of America
Michael W Mahoney
Yahoo Research, Sunnyvale, California, United States of America
Petros Drineas
Department of Computer Science, Rensselaer Polytechnic Institute, Troy, New York, United States of America

Corresponding Author

Email: ppaschou@mbg.duth.gr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PP, EZ, and PD conceived and designed the experiments. PP and PD performed the experiments and analyzed the data. All authors contributed reagents/materials/analysis tools. PP, EZ, and PD wrote the paper.