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Research Article

Nanoliter Reactors Improve Multiple Displacement Amplification of Genomes from Single Cells

  • Yann Marcy,

    Affiliations: Department of Bioengineering, Stanford University, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America

    ¤ Current address: Genewave SAS, Palaiseau, France

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  • Thomas Ishoey,

    Affiliation: J. Craig Venter Institute, La Jolla, California, United States of America

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  • Roger S Lasken,

    Affiliation: J. Craig Venter Institute, La Jolla, California, United States of America

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  • Timothy B Stockwell,

    Affiliation: J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Brian P Walenz,

    Affiliation: J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Aaron L Halpern,

    Affiliation: J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Karen Y Beeson,

    Affiliation: J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Susanne M. D Goldberg,

    Affiliation: The Joint Technology Center, J. Craig Venter Institute, Rockville, Maryland, United States of America

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  • Stephen R Quake mail

    To whom correspondence should be addressed. E-mail: quake@stanford.edu

    Affiliations: Department of Bioengineering, Stanford University, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America

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  • Published: September 21, 2007
  • DOI: 10.1371/journal.pgen.0030155

About the Authors

Yann Marcy, Stephen R Quake
Department of Bioengineering, Stanford University, Stanford, California, United States of America
Yann Marcy, Stephen R Quake
Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America
Thomas Ishoey, Roger S Lasken
J. Craig Venter Institute, La Jolla, California, United States of America
Timothy B Stockwell, Brian P Walenz, Aaron L Halpern, Karen Y Beeson
J. Craig Venter Institute, Rockville, Maryland, United States of America
Susanne M. D Goldberg
The Joint Technology Center, J. Craig Venter Institute, Rockville, Maryland, United States of America

Corresponding Author

Email: quake@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

YM, TI, RSL, and SRQ conceived and designed the experiments and wrote the paper. YM, TI, KYB, and SMDG performed the experiments. YM, TI, RSL, TBS, BPW, ALH, and SRQ analyzed the data.