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Research Article

Maintenance of Paternal Methylation and Repression of the Imprinted H19 Gene Requires MBD3

  • Kimberly J Reese,

    Affiliation: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Shu Lin,

    Affiliation: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Raluca I Verona,

    Affiliation: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Richard M Schultz,

    Affiliation: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Marisa S Bartolomei mail

    To whom correspondence should be addressed. E-mail: bartolom@mail.med.upenn.edu

    Affiliation: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: August 17, 2007
  • DOI: 10.1371/journal.pgen.0030137

About the Authors

Kimberly J Reese, Shu Lin, Raluca I Verona, Marisa S Bartolomei
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Richard M Schultz
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: bartolom@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KJR, RMS, and MSB conceived and designed the experiments. KJR, RIV, and SL performed the experiments. KJR analyzed the data with input from SL, RIV, RMS, and MSB. KJR wrote the paper with editing and other suggestions from RMS and MSB.