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Research Article

Unbiased Gene Expression Analysis Implicates the huntingtin Polyglutamine Tract in Extra-mitochondrial Energy Metabolism

  • Jong-Min Lee,

    Affiliation: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Elena V Ivanova,

    Affiliation: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    ยค Current address: Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Ihn Sik Seong,

    Affiliation: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Tanya Cashorali,

    Affiliation: Children's Hospital Informatics Program, Children's Hospital, Boston, Massachusetts, United States of America

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  • Isaac Kohane,

    Affiliation: Children's Hospital Informatics Program, Children's Hospital, Boston, Massachusetts, United States of America

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  • James F Gusella,

    Affiliations: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Huntington's Disease Society of America Coalition for the Cure Mitochondria and Energy Metabolism Team, New York, New York, United States of America

    X
  • Marcy E MacDonald mail

    To whom correspondence should be addressed. E-mail: macdonam@helix.mgh.harvard.edu

    Affiliations: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Huntington's Disease Society of America Coalition for the Cure Mitochondria and Energy Metabolism Team, New York, New York, United States of America

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  • Published: August 17, 2007
  • DOI: 10.1371/journal.pgen.0030135

About the Authors

Jong-Min Lee, Elena V Ivanova, Ihn Sik Seong, James F Gusella, Marcy E MacDonald
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Tanya Cashorali, Isaac Kohane
Children's Hospital Informatics Program, Children's Hospital, Boston, Massachusetts, United States of America
James F Gusella, Marcy E MacDonald
Huntington's Disease Society of America Coalition for the Cure Mitochondria and Energy Metabolism Team, New York, New York, United States of America

Corresponding Author

Email: macdonam@helix.mgh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JML, EVI, JFG, and MEM conceived and designed the experiments. JML, EVI, and ISS performed the experiments. JML, EVI, ISS, TC, IK, and MEM analyzed the data. JML and MEM wrote the paper, incorporating comments from EVI, ISS, TC, IK, and JFG. IK, JFG, and MEM obtained the funding to support the work.