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Research Article

Substitution as a Mechanism for Genetic Robustness: The Duplicated Deacetylases Hst1p and Sir2p in Saccharomyces cerevisiae

  • Meleah A Hickman,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, University Program in Genetics and Genomics, Duke University, Durham, North Carolina, United States of America

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  • Laura N Rusche mail

    To whom correspondence should be addressed. E-mail: lrusche@biochem.duke.edu

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Published: August 03, 2007
  • DOI: 10.1371/journal.pgen.0030126

About the Authors

Meleah A Hickman, Laura N Rusche
Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
Meleah A Hickman
University Program in Genetics and Genomics, Duke University, Durham, North Carolina, United States of America
Laura N Rusche
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America

Corresponding Author

Email: lrusche@biochem.duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MAH and LNR conceived and designed the experiments. MAH performed the experiments. MAH and LNR analyzed the data. MAH and LNR wrote the paper.