Advertisement
Research Article

Combined Effects of Thrombosis Pathway Gene Variants Predict Cardiovascular Events

  • Kirsi Auro mail,

    To whom correspondence should be addressed. E-mail: kirsi.auro@ktl.fi

    Affiliation: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland

    X
  • Mervi Alanne,

    Affiliation: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland

    X
  • Kati Kristiansson,

    Affiliation: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland

    X
  • Kaisa Silander,

    Affiliation: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland

    X
  • Kari Kuulasmaa,

    Affiliation: Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland

    X
  • Veikko Salomaa,

    Affiliation: Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland

    X
  • Leena Peltonen,

    Affiliations: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland, Department of Medical Genetics, University of Helsinki, Helsinki, Finland, The Broad Institute of MIT and Harvard, Boston, Massachusetts, United States of America

    X
  • Markus Perola

    Affiliations: Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland, Department of Medical Genetics, University of Helsinki, Helsinki, Finland

    X
  • Published: July 27, 2007
  • DOI: 10.1371/journal.pgen.0030120

About the Authors

Kirsi Auro, Mervi Alanne, Kati Kristiansson, Kaisa Silander, Leena Peltonen, Markus Perola
Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
Kari Kuulasmaa, Veikko Salomaa
Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
Leena Peltonen, Markus Perola
Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Leena Peltonen
The Broad Institute of MIT and Harvard, Boston, Massachusetts, United States of America

Corresponding Author

Email: kirsi.auro@ktl.fi

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

K. Auro was responsible for the SNP selection and the data analyses, and participated in the genotyping. M. Alanne was responsible for the sample management and participated in the genotyping and the data analyses. K. Kristiansson participated in the genotyping and the data analyses. K. Silander participated in the genotyping and the whole-genome amplification of the DNA. K. Kuulasmaa participated in the study design and the assessment of the quality of the phenotypic data and the data analyses. V. Salomaa participated in the study design, recruitment of the FINRISK participants, and assessment of the clinical diagnoses. L. Peltonen participated in the study design and the data analyses. M. Perola is the principal investigator and holds responsibility of the overall study design and the data analyses. All authors participated in writing the manuscript.