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Research Article

Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits

  • Angelo Scuteri equal contributor,

    equal contributor Contributed equally to this work with: Angelo Scuteri, Serena Sanna

    Affiliations: Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

    X
  • Serena Sanna equal contributor,

    equal contributor Contributed equally to this work with: Angelo Scuteri, Serena Sanna

    Affiliations: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America, Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Wei-Min Chen,

    Affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Manuela Uda,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Giuseppe Albai,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • James Strait,

    Affiliation: Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Samer Najjar,

    Affiliation: Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Ramaiah Nagaraja,

    Affiliation: Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Marco Orrú,

    Affiliations: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy, Unità Operativa Semplice Cardiologia, Divisione di Medicina, Presidio Ospedaliero Santa Barbara, Iglesias, Italy

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  • Gianluca Usala,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Mariano Dei,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Sandra Lai,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Andrea Maschio,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Fabio Busonero,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Antonella Mulas,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Georg B Ehret,

    Affiliation: Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Ashley A Fink,

    Affiliation: Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Alan B Weder,

    Affiliation: Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America

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  • Richard S Cooper,

    Affiliation: Department of Preventive Medicine and Epidemiology, Loyola Stritch School of Medicine, Chicago, Illinois, United States of America

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  • Pilar Galan,

    Affiliations: Institut Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France, INSERM, U557 (UMR INSERM/INRA/CNAM), Paris, France

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  • Aravinda Chakravarti,

    Affiliation: Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • David Schlessinger mail,

    To whom correspondence should be addressed. E-mail: schlessingerd@grc.nia.nih.gov (DS); goncalo@umich.edu (GRA)

    Affiliation: Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Antonio Cao,

    Affiliation: Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy

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  • Edward Lakatta,

    Affiliation: Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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  • Gonçalo R Abecasis mail

    To whom correspondence should be addressed. E-mail: schlessingerd@grc.nia.nih.gov (DS); goncalo@umich.edu (GRA)

    Affiliation: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: July 20, 2007
  • DOI: 10.1371/journal.pgen.0030115

About the Authors

Angelo Scuteri
Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy
Angelo Scuteri, James Strait, Samer Najjar, Ramaiah Nagaraja, David Schlessinger, Edward Lakatta
Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America
Serena Sanna, Wei-Min Chen, Gonçalo R Abecasis
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America
Serena Sanna, Manuela Uda, Giuseppe Albai, Marco Orrú, Gianluca Usala, Mariano Dei, Sandra Lai, Andrea Maschio, Fabio Busonero, Antonella Mulas, Antonio Cao
Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
Marco Orrú
Unità Operativa Semplice Cardiologia, Divisione di Medicina, Presidio Ospedaliero Santa Barbara, Iglesias, Italy
Georg B Ehret, Ashley A Fink, Aravinda Chakravarti
Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
Alan B Weder
Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America
Richard S Cooper
Department of Preventive Medicine and Epidemiology, Loyola Stritch School of Medicine, Chicago, Illinois, United States of America
Pilar Galan
Institut Scientifique et Technique de la Nutrition et de l'Alimentation, Paris, France
Pilar Galan
INSERM, U557 (UMR INSERM/INRA/CNAM), Paris, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

S. Najjar, G. B. Ehret, A. Chakravarti, D. Schlessinger, A. Cao, E. Lakatta, and G. R. Abecasis conceived and designed the experiments. M. Uda, G. Albai, M. Orrú, G. Usala, M. Dei, S. Lai, A. Maschio, F. Busonero, A. Mulas, G. B. Ehret, and A. A. Fink performed the experiments. S. Sanna, W.-M. Chen and G. Albai analyzed the data. S. Najjar, R. Nagaraja, A. B. Weder, R. S. Cooper, P. Galan, and A. Cao contributed reagents/materials/analysis tools. A. Scuteri, S. Sanna, J. Strait, D. Schlessinger, E. Lakatta, and G. R. Abecasis wrote the paper.