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Research Article

A Mutation in the Myostatin Gene Increases Muscle Mass and Enhances Racing Performance in Heterozygote Dogs

  • Dana S Mosher,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Pascale Quignon,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Carlos D Bustamante,

    Affiliation: Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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  • Nathan B Sutter,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Cathryn S Mellersh,

    Affiliation: Animal Health Trust, Center for Preventive Medicine, Newmarket, United Kingdom

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  • Heidi G Parker,

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Elaine A Ostrander mail

    To whom correspondence should be addressed. E-mail: eostrand@mail.nih.gov

    Affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: May 25, 2007
  • DOI: 10.1371/journal.pgen.0030079

About the Authors

Dana S Mosher, Pascale Quignon, Nathan B Sutter, Heidi G Parker, Elaine A Ostrander
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Carlos D Bustamante
Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America
Cathryn S Mellersh
Animal Health Trust, Center for Preventive Medicine, Newmarket, United Kingdom

Corresponding Author

Email: eostrand@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DSM and EAO conceived and designed the experiments. DSM and PQ performed the experiments. CDB, HGP, and NBS analyzed the data. DSM and CSM contributed reagents/materials/analysis tools. All authors contributed to writing the paper. EAO was the principal investigator and oversaw experimental design and analysis.