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Research Article

Identification of the Imprinted KLF14 Transcription Factor Undergoing Human-Specific Accelerated Evolution

  • Layla Parker-Katiraee,

    Affiliations: Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Andrew R Carson,

    Affiliations: Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Takahiro Yamada,

    Affiliations: Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada

    ¤a Current address: Department of Obstetrics and Gynaecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

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  • Philippe Arnaud,

    Affiliations: Institute of Molecular Genetics (IGMM), CNRS UMR5535, Montpellier, France, University of Montpellier II, Montpellier, France

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  • Robert Feil,

    Affiliations: Institute of Molecular Genetics (IGMM), CNRS UMR5535, Montpellier, France, University of Montpellier II, Montpellier, France

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  • Sayeda N Abu-Amero,

    Affiliation: Institute of Child Health, University College London, London, United Kingdom

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  • Gudrun E Moore,

    Affiliation: Institute of Child Health, University College London, London, United Kingdom

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  • Masahiro Kaneda,

    Affiliation: Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima, Japan

    ¤c Current address: Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge, United Kingdom

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  • George H Perry,

    Affiliation: School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona, United States of America

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  • Anne C Stone,

    Affiliation: School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona, United States of America

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  • Charles Lee,

    Affiliation: Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Makiko Meguro-Horike,

    Affiliations: Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada

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  • Hiroyuki Sasaki,

    Affiliations: Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima, Japan, Department of Genetics, School of Life Science, The Graduate University for Advanced Studies (Sokendai), Mishima, Japan

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  • Keiko Kobayashi,

    Affiliation: Department of Molecular Metabolism and Biochemical Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

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  • Kazuhiko Nakabayashi,

    Affiliations: Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada, Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima, Japan

    ¤b Current address: Department of Maternal-Fetal Biology, National Center for Child Health and Development, Setagaya, Tokyo, Japan

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  • Stephen W Scherer mail

    To whom correspondence should be addressed. E-mail: steve@genet.sickkids.on.ca

    Affiliations: Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Published: May 04, 2007
  • DOI: 10.1371/journal.pgen.0030065

About the Authors

Layla Parker-Katiraee, Andrew R Carson, Takahiro Yamada, Makiko Meguro-Horike, Kazuhiko Nakabayashi, Stephen W Scherer
Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
Layla Parker-Katiraee, Andrew R Carson, Takahiro Yamada, Makiko Meguro-Horike, Kazuhiko Nakabayashi, Stephen W Scherer
The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada
Layla Parker-Katiraee, Andrew R Carson, Stephen W Scherer
Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada
Philippe Arnaud, Robert Feil
Institute of Molecular Genetics (IGMM), CNRS UMR5535, Montpellier, France
Philippe Arnaud, Robert Feil
University of Montpellier II, Montpellier, France
Sayeda N Abu-Amero, Gudrun E Moore
Institute of Child Health, University College London, London, United Kingdom
Masahiro Kaneda, Hiroyuki Sasaki, Kazuhiko Nakabayashi
Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima, Japan
George H Perry, Anne C Stone
School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona, United States of America
Charles Lee
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Hiroyuki Sasaki
Department of Genetics, School of Life Science, The Graduate University for Advanced Studies (Sokendai), Mishima, Japan
Keiko Kobayashi
Department of Molecular Metabolism and Biochemical Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Corresponding Author

Email: steve@genet.sickkids.on.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LPK, ARC, TY, HS, KN, and SWS conceived and designed the experiments. LPK, TY, PA, SNAA, GHP, MMH, and KN performed the experiments. LPK, ARC, TY, PA, RF, GHP, KN, and SWS analyzed the data. LPK, TY, SNAA, GEM, MK, GHP, ACS, CL, HS, KK, and KN contributed reagents/materials/analysis tools. LPK, ARC, and RF wrote the paper.