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Research Article

PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism

  • Gema Medina-Gomez,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Sarah L Gray,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Laxman Yetukuri,

    Affiliation: Technical Research Centre of Finland (VTT), Espoo, Finland

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  • Kenju Shimomura,

    Affiliation: University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom

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  • Sam Virtue,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Mark Campbell,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • R. Keira Curtis,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Mercedes Jimenez-Linan,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Margaret Blount,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Giles S. H Yeo,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Miguel Lopez,

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Tuulikki Seppänen-Laakso,

    Affiliation: Technical Research Centre of Finland (VTT), Espoo, Finland

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  • Frances M Ashcroft,

    Affiliation: University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom

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  • Matej Orešič,

    Affiliation: Technical Research Centre of Finland (VTT), Espoo, Finland

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  • Antonio Vidal-Puig mail

    To whom correspondence should be addressed. E-mail: ajv22@cam.ac.uk

    Affiliation: Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Published: April 27, 2007
  • DOI: 10.1371/journal.pgen.0030064

About the Authors

Gema Medina-Gomez, Sarah L Gray, Sam Virtue, Mark Campbell, R. Keira Curtis, Mercedes Jimenez-Linan, Margaret Blount, Giles S. H Yeo, Miguel Lopez, Antonio Vidal-Puig
Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom
Laxman Yetukuri, Tuulikki Seppänen-Laakso, Matej Orešič
Technical Research Centre of Finland (VTT), Espoo, Finland
Kenju Shimomura, Frances M Ashcroft
University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: ajv22@cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

GMG, SLG, FMA, and AVP conceived and designed the experiments. GMG, SLG, LY, KS, SV, MB, ML, and MO performed the experiments. GMG, SLG, LY, KS, SV, MC, RKC, MJL, TSL, and MO analysed the data. GMG, LY, KS, SV, MC, RKC, MB, and GSHY contributed reagents/materials/analysis tools. GMG and AVP wrote the paper.