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Research Article

Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4

  • Cécile Libioulle,

    Affiliation: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

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  • Edouard Louis,

    Affiliation: Unit of Hepatology and Gastroenterology, Department of Clinical Sciences, GIGA-R, Faculty of Medicine, and CHU de Liège, University of Liège, Liège, Belgium

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  • Sarah Hansoul,

    Affiliation: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

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  • Cynthia Sandor,

    Affiliation: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

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  • Frédéric Farnir,

    Affiliation: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

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  • Denis Franchimont,

    Affiliation: Department of Gastroenterology, Erasmus Hospital, Free University of Brussels, Brussels, Belgium

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  • Séverine Vermeire,

    Affiliation: Department of Gastroenterology, University Hospital Leuven, Leuven, Belgium

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  • Olivier Dewit,

    Affiliation: Department of Gastroenterology, Clinique Universitaire St Luc, UCL, Brussels, Belgium

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  • Martine de Vos,

    Affiliation: Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium

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  • Anna Dixon,

    Affiliation: National Heart and Lung Institute, Imperial College London, England

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  • Bruno Demarche,

    Affiliation: Unit of Bioinformatics, GIGA-R and Institut Montefiore, University of Liège, Liège, Belgium

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  • Ivo Gut,

    Affiliation: Centre National de Génotypage, Evry, France

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  • Simon Heath,

    Affiliation: Centre National de Génotypage, Evry, France

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  • Mario Foglio,

    Affiliation: Centre National de Génotypage, Evry, France

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  • Liming Liang,

    Affiliation: Centre for Statistical Genetics, Department of Biostatistics, Ann Arbor, Michigan, United States

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  • Debby Laukens,

    Affiliation: Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium

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  • Myriam Mni,

    Affiliation: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

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  • Diana Zelenika,

    Affiliation: Centre National de Génotypage, Evry, France

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  • André Van Gossum,

    Affiliation: Department of Gastroenterology, Erasmus Hospital, Free University of Brussels, Brussels, Belgium

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  • Paul Rutgeerts,

    Affiliation: Department of Gastroenterology, University Hospital Leuven, Leuven, Belgium

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  • Jacques Belaiche,

    Affiliation: Unit of Hepatology and Gastroenterology, Department of Clinical Sciences, GIGA-R, Faculty of Medicine, and CHU de Liège, University of Liège, Liège, Belgium

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  • Mark Lathrop,

    Affiliation: Centre National de Génotypage, Evry, France

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  • Michel Georges mail

    To whom correspondence should be addressed. E-mail: michel.georges@ulg.ac.be

    Affiliation: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium

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  • Published: April 20, 2007
  • DOI: 10.1371/journal.pgen.0030058

About the Authors

Cécile Libioulle, Sarah Hansoul, Cynthia Sandor, Frédéric Farnir, Myriam Mni, Michel Georges
Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium
Edouard Louis, Jacques Belaiche
Unit of Hepatology and Gastroenterology, Department of Clinical Sciences, GIGA-R, Faculty of Medicine, and CHU de Liège, University of Liège, Liège, Belgium
Denis Franchimont, André Van Gossum
Department of Gastroenterology, Erasmus Hospital, Free University of Brussels, Brussels, Belgium
Séverine Vermeire, Paul Rutgeerts
Department of Gastroenterology, University Hospital Leuven, Leuven, Belgium
Olivier Dewit
Department of Gastroenterology, Clinique Universitaire St Luc, UCL, Brussels, Belgium
Martine de Vos, Debby Laukens
Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium
Anna Dixon
National Heart and Lung Institute, Imperial College London, England
Bruno Demarche
Unit of Bioinformatics, GIGA-R and Institut Montefiore, University of Liège, Liège, Belgium
Ivo Gut, Simon Heath, Mario Foglio, Diana Zelenika, Mark Lathrop
Centre National de Génotypage, Evry, France
Liming Liang
Centre for Statistical Genetics, Department of Biostatistics, Ann Arbor, Michigan, United States

Corresponding Author

Email: michel.georges@ulg.ac.be

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

E. Louis, M. Lathrop, and M. Georges conceived and designed the experiments. C. Libioulle, A. Dixon, I. Gut, M. Mni, and D. Zelenika performed the experiments. C. Libioulle, E. Louis, S. Hansoul, C. Sandor, F. Farnir, B. Demarche, M. Foglio, S. Heath, L. Liang, M. Lathrop, and M. Georges analyzed the data. E. Louis, D. Franchimont, S. Vermeire, O. Dewit, M. de Vos, D. Laukens, A. Van Gossum, P. Rutgeerts, and J. Belaiche contributed reagents/materials/analysis tools. M. Lathrop and M. Georges wrote the paper.