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Research Article

Genome-Wide Linkage Analysis of Malaria Infection Intensity and Mild Disease

  • Christian Timmann mail,

    To whom correspondence should be addressed. E-mail: timmann@bni-hamburg.de

    Affiliations: Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, University at Lübeck, Lübeck, Germany

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  • Jennifer A Evans,

    Affiliations: Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana

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  • Inke R König,

    Affiliation: Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, University at Lübeck, Lübeck, Germany

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  • André Kleensang,

    Affiliation: Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, University at Lübeck, Lübeck, Germany

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  • Franz Rüschendorf,

    Affiliation: Max Delbrück Centre for Molecular Medicine, Berlin, Germany

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  • Julia Lenzen,

    Affiliation: Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

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  • Jürgen Sievertsen,

    Affiliation: Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

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  • Christian Becker,

    Affiliations: Max Delbrück Centre for Molecular Medicine, Berlin, Germany, Cologne Center for Genomics, University of Cologne, Cologne, Germany

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  • Yeetey Enuameh,

    Affiliation: Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana

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  • Kingsley Osei Kwakye,

    Affiliation: Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana

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  • Ernest Opoku,

    Affiliation: Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana

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  • Edmund N. L Browne,

    Affiliation: Department of Community Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

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  • Andreas Ziegler,

    Affiliation: Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, University at Lübeck, Lübeck, Germany

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  • Peter Nürnberg,

    Affiliations: Max Delbrück Centre for Molecular Medicine, Berlin, Germany, Cologne Center for Genomics, University of Cologne, Cologne, Germany

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  • Rolf D Horstmann

    Affiliation: Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

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  • Published: March 23, 2007
  • DOI: 10.1371/journal.pgen.0030048

About the Authors

Christian Timmann, Jennifer A Evans, Julia Lenzen, Jürgen Sievertsen, Rolf D Horstmann
Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Christian Timmann, Inke R König, André Kleensang, Andreas Ziegler
Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, University at Lübeck, Lübeck, Germany
Jennifer A Evans, Yeetey Enuameh, Kingsley Osei Kwakye, Ernest Opoku
Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana
Franz Rüschendorf, Christian Becker, Peter Nürnberg
Max Delbrück Centre for Molecular Medicine, Berlin, Germany
Christian Becker, Peter Nürnberg
Cologne Center for Genomics, University of Cologne, Cologne, Germany
Edmund N. L Browne
Department of Community Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

Corresponding Author

Email: timmann@bni-hamburg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CT and RDH designed the study. CT, IRK, AK, FR, and JL analyzed the data. JAE and ENLB organized and supervised the phenotyping. JL, YE, KOK, and EO performed the phenotyping. PN supervised the genotyping. FR, JS, and CB performed the genotyping. IRK and AZ designed and supervised the data analysis. CT, AZ, and RDH wrote the paper.