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Research Article

The Molecular Basis of High-Altitude Adaptation in Deer Mice

  • Jay F Storz mail,

    To whom correspondence should be addressed. E-mail: jstorz2@unl.edu

    Affiliation: School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America

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  • Stephen J Sabatino,

    Affiliation: School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America

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  • Federico G Hoffmann,

    Affiliation: School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America

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  • Eben J Gering,

    Affiliation: School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America

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  • Hideaki Moriyama,

    Affiliation: Department of Chemistry, University of Nebraska, Lincoln, Nebraska, United States of America

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  • Nuno Ferrand,

    Affiliations: Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Universidade do Porto, Vairão, Portugal, Departamento de Zoologia e Anthropologia, Faculdade de Ciências do Porto, Porto, Portugal

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  • Bruno Monteiro,

    Affiliations: Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Universidade do Porto, Vairão, Portugal, Departamento de Zoologia e Anthropologia, Faculdade de Ciências do Porto, Porto, Portugal

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  • Michael W Nachman

    Affiliation: Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America

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  • Published: March 30, 2007
  • DOI: 10.1371/journal.pgen.0030045

About the Authors

Jay F Storz, Stephen J Sabatino, Federico G Hoffmann, Eben J Gering
School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America
Hideaki Moriyama
Department of Chemistry, University of Nebraska, Lincoln, Nebraska, United States of America
Nuno Ferrand, Bruno Monteiro
Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Universidade do Porto, Vairão, Portugal
Nuno Ferrand, Bruno Monteiro
Departamento de Zoologia e Anthropologia, Faculdade de Ciências do Porto, Porto, Portugal
Michael W Nachman
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America

Corresponding Author

Email: jstorz2@unl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JFS and MWN conceived and designed the project. JFS and EJG conducted the field work. JFS, SJS, FGH, EJG, NF, and BM collected the molecular data, JFS and HM analyzed the data, and JFS wrote the paper.