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Research Article

Inducible and Reversible Clock Gene Expression in Brain Using the tTA System for the Study of Circadian Behavior

  • Hee-Kyung Hong,

    Affiliations: Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, United States of America, Center for Functional Genomics, Northwestern University, Evanston, Illinois, United States of America, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America

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  • Jason L Chong,

    Affiliation: Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America

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  • Weimin Song,

    Affiliations: Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, United States of America, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America

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  • Eun Joo Song,

    Affiliations: Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, United States of America, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America

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  • Amira A Jyawook,

    Affiliations: Center for Functional Genomics, Northwestern University, Evanston, Illinois, United States of America, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America

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  • Andrew C Schook,

    Affiliations: Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, United States of America, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America

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  • Caroline H Ko,

    Affiliations: Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America, Department of Psychology, University of Toronto, Toronto, Ontario, Canada

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  • Joseph S Takahashi mail

    To whom correspondence should be addressed. E-mail: j-takahashi@northwestern.edu

    Affiliations: Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, United States of America, Center for Functional Genomics, Northwestern University, Evanston, Illinois, United States of America, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America

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  • Published: February 23, 2007
  • DOI: 10.1371/journal.pgen.0030033

About the Authors

Hee-Kyung Hong, Weimin Song, Eun Joo Song, Andrew C Schook, Joseph S Takahashi
Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois, United States of America
Hee-Kyung Hong, Amira A Jyawook, Joseph S Takahashi
Center for Functional Genomics, Northwestern University, Evanston, Illinois, United States of America
Hee-Kyung Hong, Jason L Chong, Weimin Song, Eun Joo Song, Amira A Jyawook, Andrew C Schook, Caroline H Ko, Joseph S Takahashi
Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America
Caroline H Ko
Department of Psychology, University of Toronto, Toronto, Ontario, Canada

Corresponding Author

Email: j-takahashi@northwestern.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

HKH, JLC, and JST conceived and designed the experiments. HKH, JLC, WS, EJS, AAJ, ACS, and CHK performed the experiments. HKH analyzed the data and contributed reagents/materials/analysis tools. HKH and JST wrote the paper.