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Research Article

Genomic Relationships and Speciation Times of Human, Chimpanzee, and Gorilla Inferred from a Coalescent Hidden Markov Model

  • Asger Hobolth mail,

    To whom correspondence should be addressed. E-mail: asger@daimi.au.dk

    Affiliation: Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America

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  • Ole F Christensen,

    Affiliation: Bioinformatics Research Center, University of Aarhus, Aarhus, Denmark

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  • Thomas Mailund,

    Affiliations: Bioinformatics Research Center, University of Aarhus, Aarhus, Denmark, Department of Statistics, University of Oxford, Oxford, United Kingdom

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  • Mikkel H Schierup

    Affiliation: Bioinformatics Research Center, University of Aarhus, Aarhus, Denmark

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  • Published: February 23, 2007
  • DOI: 10.1371/journal.pgen.0030007

About the Authors

Asger Hobolth
Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America
Ole F Christensen, Thomas Mailund, Mikkel H Schierup
Bioinformatics Research Center, University of Aarhus, Aarhus, Denmark
Thomas Mailund
Department of Statistics, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: asger@daimi.au.dk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AH, OFC, and MHS conceived and designed the study. AH and MHS analyzed the data. AH developed coal-HMM methodology and software. OFC performed simulation studies. OFC and MHS contributed to coal-HMM methodology. TM wrote simulation software. TM and MHS prepared alignments for data analysis. AH, OFC, and MHS wrote the paper.