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Research Article

A High-Resolution Map of Synteny Disruptions in Gibbon and Human Genomes

  • Lucia Carbone equal contributor mail,

    equal contributor Contributed equally to this work with: Lucia Carbone, Gery M Vessere

    To whom correspondence should be addressed. E-mail: lcarbone@chori.org

    Affiliation: BACPAC Resources, Children's Hospital of Oakland Research Institute, Oakland, California, United States of America

    X
  • Gery M Vessere equal contributor,

    equal contributor Contributed equally to this work with: Lucia Carbone, Gery M Vessere

    Affiliation: BACPAC Resources, Children's Hospital of Oakland Research Institute, Oakland, California, United States of America

    X
  • Boudewijn F.H. ten Hallers,

    Affiliation: BACPAC Resources, Children's Hospital of Oakland Research Institute, Oakland, California, United States of America

    X
  • Baoli Zhu,

    Affiliation: BACPAC Resources, Children's Hospital of Oakland Research Institute, Oakland, California, United States of America

    X
  • Kazutoyo Osoegawa,

    Affiliation: BACPAC Resources, Children's Hospital of Oakland Research Institute, Oakland, California, United States of America

    X
  • Alan Mootnick,

    Affiliation: Gibbon Conservation Center, Santa Clarita, California, United States of America

    X
  • Andrea Kofler,

    Affiliation: Chrombios GmbH, Raubling, Germany

    X
  • Johannes Wienberg,

    Affiliation: Anthropology and Human Genetics, Department of Biology II, Munich University, Munich, Germany

    X
  • Jane Rogers,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom

    X
  • Sean Humphray,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom

    X
  • Carol Scott,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom

    X
  • R. Alan Harris,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Aleksandar Milosavljevic,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Pieter J de Jong

    Affiliation: BACPAC Resources, Children's Hospital of Oakland Research Institute, Oakland, California, United States of America

    X
  • Published: December 29, 2006
  • DOI: 10.1371/journal.pgen.0020223

About the Authors

Lucia Carbone, Gery M Vessere, Boudewijn F.H. ten Hallers, Baoli Zhu, Kazutoyo Osoegawa, Pieter J de Jong
BACPAC Resources, Children's Hospital of Oakland Research Institute, Oakland, California, United States of America
Alan Mootnick
Gibbon Conservation Center, Santa Clarita, California, United States of America
Andrea Kofler
Chrombios GmbH, Raubling, Germany
Johannes Wienberg
Anthropology and Human Genetics, Department of Biology II, Munich University, Munich, Germany
Jane Rogers, Sean Humphray, Carol Scott
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
R. Alan Harris, Aleksandar Milosavljevic
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Corresponding Author

Email: lcarbone@chori.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LC and PJdJ conceived and designed the experiments. LC, AK, and JW performed the experiments. GMV, CS, RAH, and AM analyzed the data. BFHtH, BZ, KO, AM, JW, JR, and SH contributed reagents/materials/analysis tools. LC, GMV, and PJdJ wrote the paper.