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Research Article

Adaptive Stress Response in Segmental Progeria Resembles Long-Lived Dwarfism and Calorie Restriction in Mice

  • Marieke van de Ven equal contributor,

    equal contributor Contributed equally to this work with: Marieke van de Ven, Jaan-Olle Andressoo

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Jaan-Olle Andressoo equal contributor,

    equal contributor Contributed equally to this work with: Marieke van de Ven, Jaan-Olle Andressoo

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands

    ¤ Current address: Institute of Biotechnology, University of Helsinki, Finland

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  • Valerie B Holcomb,

    Affiliation: Department of Molecular Medicine, University of Texas/Institute of Biotechnology, San Antonio, Texas, United States of America

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  • Marieke von Lindern,

    Affiliation: Department of Hematology, Erasmus MC, Rotterdam, The Netherlands

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  • Willeke M. C Jong,

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Chris I. De Zeeuw,

    Affiliation: Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands

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  • Yousin Suh,

    Affiliation: Department of Molecular Medicine, University of Texas/Institute of Biotechnology, San Antonio, Texas, United States of America

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  • Paul Hasty,

    Affiliation: Department of Molecular Medicine, University of Texas/Institute of Biotechnology, San Antonio, Texas, United States of America

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  • Jan H. J Hoeijmakers,

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Gijsbertus T. J van der Horst,

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands

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  • James R Mitchell mail

    To whom correspondence should be addressed. E-mail: j.mitchell@erasmusmc.nl

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Published: December 15, 2006
  • DOI: 10.1371/journal.pgen.0020192

About the Authors

Marieke van de Ven, Jaan-Olle Andressoo, Willeke M. C Jong, Jan H. J Hoeijmakers, Gijsbertus T. J van der Horst, James R Mitchell
Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
Valerie B Holcomb, Yousin Suh, Paul Hasty
Department of Molecular Medicine, University of Texas/Institute of Biotechnology, San Antonio, Texas, United States of America
Marieke von Lindern
Department of Hematology, Erasmus MC, Rotterdam, The Netherlands
Chris I. De Zeeuw
Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands

Corresponding Author

Email: j.mitchell@erasmusmc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MvdV, JOA, YS, PH, JHJH, GTJvdH, and JRM conceived and designed the experiments. MvdV, JOA, VBH, MvL, WMCJ, CIDZ, and JRM performed the experiments. MvdV, JOA, VBH, MvL, WMCJ, CIDZ, and JRM analyzed the data. YS, PH, JHJH, and GTJvdH contributed reagents/materials/analysis tools. MvdV, JOA, and JRM wrote the paper.