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Research Article

RanBP2 Modulates Cox11 and Hexokinase I Activities and Haploinsufficiency of RanBP2 Causes Deficits in Glucose Metabolism

  • Azamat Aslanukov equal contributor,

    equal contributor Contributed equally to this work with: Azamat Aslanukov, Reshma Bhowmick

    Affiliation: Third Wave Technologies, Madison, Wisconsin, United States of America

    ¤ Current address: Fugent LLC, Madison, Wisconsin, United States of America

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  • Reshma Bhowmick equal contributor,

    equal contributor Contributed equally to this work with: Azamat Aslanukov, Reshma Bhowmick

    Affiliation: Department of Anatomy, Cell Biology, and Neurobiology, Medical College of Wisconsin, Milwaukee, United States of America

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  • Mallikarjuna Guruju,

    Affiliation: Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • John Oswald,

    Affiliation: Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Dorit Raz,

    Affiliation: National Institutes of Health, National Institute on Deafness and Other Communication Disorders/National Eye Institute, Bethesda, Maryland, United States of America

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  • Ronald A Bush,

    Affiliation: National Institutes of Health, National Institute on Deafness and Other Communication Disorders/National Eye Institute, Bethesda, Maryland, United States of America

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  • Paul A Sieving,

    Affiliation: National Institutes of Health, National Eye Institute, Bethesda, Maryland, United States of America

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  • Xinrong Lu,

    Affiliation: Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Cheryl B Bock,

    Affiliation: Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Paulo A Ferreira mail

    To whom correspondence should be addressed. E-mail: ferre044@mc.duke.edu

    Affiliations: Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Published: October 27, 2006
  • DOI: 10.1371/journal.pgen.0020177

About the Authors

Azamat Aslanukov
Third Wave Technologies, Madison, Wisconsin, United States of America
Reshma Bhowmick
Department of Anatomy, Cell Biology, and Neurobiology, Medical College of Wisconsin, Milwaukee, United States of America
Mallikarjuna Guruju, John Oswald, Xinrong Lu, Paulo A Ferreira
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States of America
Dorit Raz, Ronald A Bush
National Institutes of Health, National Institute on Deafness and Other Communication Disorders/National Eye Institute, Bethesda, Maryland, United States of America
Paul A Sieving
National Institutes of Health, National Eye Institute, Bethesda, Maryland, United States of America
Cheryl B Bock
Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina, United States of America
Paulo A Ferreira
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

Corresponding Author

Email: ferre044@mc.duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AA, RB, MG, DR, RAB, and PAF conceived and designed the experiments. AA, RB, MG, JO, DR, XL, and CBB performed the experiments. AA, RB, MG, JO, DR, RAB, PAS, and PAF analyzed the data. PAF contributed reagents/materials/analysis tools. PAF wrote the paper.