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Research Article

Forces Shaping the Fastest Evolving Regions in the Human Genome

  • Katherine S Pollard mail,

    To whom correspondence should be addressed. E-mail: kspollard@ucdavis.edu

    Affiliation: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

    ¤a Current address: Genome Center and Department of Statistics, University of California Davis, Davis, California, United States of America

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  • Sofie R Salama,

    Affiliations: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America, Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Bryan King,

    Affiliations: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America, Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Andrew D Kern,

    Affiliation: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Tim Dreszer,

    Affiliation: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Sol Katzman,

    Affiliations: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America, Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Adam Siepel,

    Affiliation: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

    ¤b Current address: Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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  • Jakob S Pedersen,

    Affiliation: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Gill Bejerano,

    Affiliation: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Robert Baertsch,

    Affiliation: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Kate R Rosenbloom,

    Affiliation: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Jim Kent,

    Affiliation: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • David Haussler

    Affiliations: Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America, Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, California, United States of America

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  • Published: October 13, 2006
  • DOI: 10.1371/journal.pgen.0020168

About the Authors

Katherine S Pollard, Sofie R Salama, Bryan King, Andrew D Kern, Tim Dreszer, Sol Katzman, Adam Siepel, Jakob S Pedersen, Gill Bejerano, Robert Baertsch, Kate R Rosenbloom, Jim Kent, David Haussler
Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, United States of America
Sofie R Salama, Bryan King, Sol Katzman, David Haussler
Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, California, United States of America

Corresponding Author

Email: kspollard@ucdavis.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KSP, SRS, ADK, and DH conceived and designed the experiments. KSP, SRS, BK, ADK, TD, and SK performed the experiments. KSP, SRS, BK, ADK, TD, AS, JSP, and DH analyzed the data. KSP, ADK, AS, JSP, GB, RB, KRR, and JK contributed reagents/materials/analysis tools. KSP, ADK, and DH wrote the paper.