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Research Article

Constitutive Nucleosome Depletion and Ordered Factor Assembly at the GRP78 Promoter Revealed by Single Molecule Footprinting

  • Einav Nili Gal-Yam,

    Affiliations: Department of Urology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Shinwu Jeong,

    Affiliations: Department of Urology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Amos Tanay,

    Affiliation: Center for Studies in Physics and Biology, Rockefeller University, New York, New York, United States of America

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  • Gerda Egger,

    Affiliations: Department of Urology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Amy S Lee,

    Affiliation: Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Peter A Jones mail

    To whom correspondence should be addressed. E-mail: jones_p@ccnt.hsc.usc.edu

    Affiliations: Department of Urology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Published: September 22, 2006
  • DOI: 10.1371/journal.pgen.0020160

About the Authors

Einav Nili Gal-Yam, Shinwu Jeong, Gerda Egger, Peter A Jones
Department of Urology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Einav Nili Gal-Yam, Shinwu Jeong, Gerda Egger, Amy S Lee, Peter A Jones
Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Amos Tanay
Center for Studies in Physics and Biology, Rockefeller University, New York, New York, United States of America

Corresponding Author

Email: jones_p@ccnt.hsc.usc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ENGY, ASL, and PAJ conceived and designed the experiments. ENGY and SJ performed the experiments. ENGY analyzed the data. AT perfomed computational analysis and helped with manuscript preparation. GE provided assistance with experiments. ASL and PAJ edited the manuscript. ENGY wrote the paper.