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Research Article

Analysis of Pleiotropic Transcriptional Profiles: A Case Study of DNA Gyrase Inhibition

  • Kyeong Soo Jeong,

    Affiliations: Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, St. Paul, Minnesota, United States of America, Biotechnology Institute, University of Minnesota, St. Paul, Minnesota, United States of America

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  • Yang Xie,

    Affiliations: Biotechnology Institute, University of Minnesota, St. Paul, Minnesota, United States of America, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Hiroshi Hiasa,

    Affiliation: Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

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  • Arkady B Khodursky mail

    To whom correspondence should be addressed. E-mail: khodu001@umn.edu

    Affiliations: Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, St. Paul, Minnesota, United States of America, Biotechnology Institute, University of Minnesota, St. Paul, Minnesota, United States of America

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  • Published: September 29, 2006
  • DOI: 10.1371/journal.pgen.0020152

About the Authors

Kyeong Soo Jeong, Arkady B Khodursky
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, St. Paul, Minnesota, United States of America
Kyeong Soo Jeong, Yang Xie, Arkady B Khodursky
Biotechnology Institute, University of Minnesota, St. Paul, Minnesota, United States of America
Yang Xie
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America
Hiroshi Hiasa
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

Corresponding Author

Email: khodu001@umn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KSJ and ABK conceived and designed the experiments. KSJ and HH performed the experiments. KSJ, YX, and ABK analyzed the data. HH and ABK contributed reagents/materials/analysis tools. KSJ and ABK wrote the paper.