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Research Article

European Population Substructure: Clustering of Northern and Southern Populations

  • Michael F Seldin mail,

    To whom correspondence should be addressed. E-mail: mfseldin@ucdavis.edu

    Affiliation: Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California Davis, Davis, California, United States of America

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  • Russell Shigeta,

    Affiliation: Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California Davis, Davis, California, United States of America

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  • Pablo Villoslada,

    Affiliation: Center for Applied Medical Research, University of Navarra, Pamplona, Spain

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  • Carlo Selmi,

    Affiliations: Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Milan, Italy, Department of Medicine, University of California Davis, Davis, California, United States of America

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  • Jaakko Tuomilehto,

    Affiliations: Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland, South Ostrobothnia Central Hospital, Seinajoki, Finland

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  • Gabriel Silva,

    Affiliation: Obras Sociales del Hermano Pedro, Antigua, Guatemala

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  • John W Belmont,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Lars Klareskog,

    Affiliation: Karolinska University Hospital, Stockholm, Sweden

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  • Peter K Gregersen

    Affiliation: The Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, United States of America

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  • Published: September 15, 2006
  • DOI: 10.1371/journal.pgen.0020143

About the Authors

Michael F Seldin, Russell Shigeta
Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California Davis, Davis, California, United States of America
Pablo Villoslada
Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Carlo Selmi
Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Milan, Italy
Carlo Selmi
Department of Medicine, University of California Davis, Davis, California, United States of America
Jaakko Tuomilehto
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
Jaakko Tuomilehto
South Ostrobothnia Central Hospital, Seinajoki, Finland
Gabriel Silva
Obras Sociales del Hermano Pedro, Antigua, Guatemala
John W Belmont
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
Lars Klareskog
Karolinska University Hospital, Stockholm, Sweden
Peter K Gregersen
The Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, United States of America

Corresponding Author

Email: mfseldin@ucdavis.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The study was conceived by MFS and designed by MFS and PKG. MFS, RS, PV, CS, JT, GS, JWB, LK, and PKG recruited participants, and obtained and prepared DNA samples used in these studies. Analyses were performed by MFS and PKG. The manuscript was written by MFS and PKG with contributions from PV, CS, JT, GS, JWB, and LK.