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Research Article

Regional Admixture Mapping and Structured Association Testing: Conceptual Unification and an Extensible General Linear Model

  • David T Redden mail,

    To whom correspondence should be addressed. E-mail: DRedden@UAB.edu

    Affiliations: Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Jasmin Divers,

    Affiliation: Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Laura Kelly Vaughan,

    Affiliation: Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Hemant K Tiwari,

    Affiliation: Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • T. Mark Beasley,

    Affiliation: Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • José R Fernández,

    Affiliations: Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Robert P Kimberly,

    Affiliation: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Rui Feng,

    Affiliation: Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Miguel A Padilla,

    Affiliation: Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Nianjun Liu,

    Affiliation: Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Michael B Miller,

    Affiliation: Division of Epidemiology, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • David B Allison

    Affiliations: Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Published: August 25, 2006
  • DOI: 10.1371/journal.pgen.0020137

About the Authors

David T Redden, Jasmin Divers, Laura Kelly Vaughan, Hemant K Tiwari, T. Mark Beasley, José R Fernández, Rui Feng, Miguel A Padilla, Nianjun Liu, David B Allison
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
David T Redden, José R Fernández, David B Allison
Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
José R Fernández, David B Allison
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Robert P Kimberly
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Michael B Miller
Division of Epidemiology, University of Minnesota, Minneapolis, Minnesota, United States of America

Corresponding Author

Email: DRedden@UAB.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DTR, JD, TMB, MBM, and DBA conceived and designed the experiments. DTR, JD, and DBA performed the experiments. DTR, JD, LKV, and DBA analyzed the data. DTR, JD, HKT, JRF, MAP, and DBA contributed reagents/materials/analysis tools. DTR, JD, LKV, HKT, TMB, RPK, RF, MAP, NL, MBM, and DBA wrote the paper.