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Research Article

Family-Based versus Unrelated Case-Control Designs for Genetic Associations

  • Evangelos Evangelou,

    Affiliation: Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece

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  • Thomas A Trikalinos,

    Affiliations: Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece, Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, Massachusetts, United States of America

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  • Georgia Salanti,

    Affiliation: Biostatistics Unit, Medical Research Council, Cambridge, United Kingdom

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  • John P. A Ioannidis mail

    To whom correspondence should be addressed. E-mail: jioannid@cc.uoi.gr

    Affiliations: Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece, Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece

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  • Published: August 11, 2006
  • DOI: 10.1371/journal.pgen.0020123

About the Authors

Evangelos Evangelou, Thomas A Trikalinos, John P. A Ioannidis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Thomas A Trikalinos, John P. A Ioannidis
Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, Massachusetts, United States of America
Georgia Salanti
Biostatistics Unit, Medical Research Council, Cambridge, United Kingdom
John P. A Ioannidis
Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece

Corresponding Author

Email: jioannid@cc.uoi.gr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

EE, TAT, GS, and JPAI conceived and designed the experiments. EE, TAT, GS, and JPAI analyzed the data. TAT and GS commented critically on the manuscript. EE and JPAI wrote the paper.