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Research Article

Human Imprinted Chromosomal Regions Are Historical Hot-Spots of Recombination

  • Ionel Sandovici,

    Affiliation: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

    ¤a Current address: Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom

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  • Sacha Kassovska-Bratinova,

    Affiliation: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Joe E Vaughan,

    Affiliation: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

    ¤b Current address: Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America

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  • Rae Stewart,

    Affiliation: College of Science and Technology, Temple University, Philadelphia, Pennsylvania, United States of America

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  • Mark Leppert,

    Affiliation: Eccles Institute of Human Genetics, and Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America

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  • Carmen Sapienza mail

    To whom correspondence should be addressed. E-mail: sapienza@temple.edu

    Affiliations: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: July 07, 2006
  • DOI: 10.1371/journal.pgen.0020101

About the Authors

Ionel Sandovici, Sacha Kassovska-Bratinova, Joe E Vaughan, Carmen Sapienza
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
Rae Stewart
College of Science and Technology, Temple University, Philadelphia, Pennsylvania, United States of America
Mark Leppert
Eccles Institute of Human Genetics, and Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America
Carmen Sapienza
Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: sapienza@temple.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

IS and CS conceived and designed the experiments. IS, SKB, JEV, and RS performed the experiments. IS, SKB, and CS analyzed the data. ML contributed reagents/materials/analysis tools. IS and CS wrote the paper.