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Research Article

Nuclear mRNA Degradation Pathway(s) Are Implicated in Xist Regulation and X Chromosome Inactivation

  • Constance Ciaudo,

    Affiliation: Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France

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  • Agnès Bourdet,

    Affiliation: Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France

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  • Michel Cohen-Tannoudji,

    Affiliation: Unité de Biologie du Développement, Institut Pasteur, Paris, France

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  • Harry C Dietz,

    Affiliation: Institute of Genetic Medicine and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Claire Rougeulle,

    Affiliation: Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France

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  • Philip Avner mail

    To whom correspondence should be addressed. E-mail: pavner@pasteur.fr

    Affiliation: Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France

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  • Published: June 16, 2006
  • DOI: 10.1371/journal.pgen.0020094

About the Authors

Constance Ciaudo, Agnès Bourdet, Claire Rougeulle, Philip Avner
Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France
Michel Cohen-Tannoudji
Unité de Biologie du Développement, Institut Pasteur, Paris, France
Harry C Dietz
Institute of Genetic Medicine and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Corresponding Author

Email: pavner@pasteur.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CC, AB, MC, HCD, and PA conceived and designed the experiments. CC, AB, and CR performed the experiments. CC, MC, HCD, CR, and PA analyzed the data. CC, HC, and CR contributed reagents/materials/analysis tools. CC, MC, CR, and PA wrote the paper.