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Research Article

Genome-Wide Mapping of Susceptibility to Coronary Artery Disease Identifies a Novel Replicated Locus on Chromosome 17

  • Martin Farrall equal contributor,

    equal contributor Contributed equally to this work with: Martin Farrall, Fiona R Green

    Affiliation: Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

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  • Fiona R Green equal contributor,

    equal contributor Contributed equally to this work with: Martin Farrall, Fiona R Green

    Affiliation: School of Biomedical and Molecular Sciences, University of Surrey, Guildford, United Kingdom

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  • John F Peden,

    Affiliation: Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

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  • Per G Olsson,

    Affiliation: AstraZeneca AB, Mölndal, Sweden

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  • Robert Clarke,

    Affiliation: Clinical Trials Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom

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  • Mai-Lis Hellenius,

    Affiliation: Department of Medicine, Karolinska Institute, Stockholm, Sweden

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  • Stephan Rust,

    Affiliation: Leibniz—Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany

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  • Jacob Lagercrantz,

    Affiliation: Department of Medicine, Karolinska Institute, Stockholm, Sweden

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  • Maria Grazia Franzosi,

    Affiliation: Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy

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  • Helmut Schulte,

    Affiliation: Leibniz—Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany

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  • Alisoun Carey,

    Affiliation: Oxagen Limited, Abingdon, Oxfordshire, United Kingdom

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  • Gunnar Olsson,

    Affiliation: AstraZeneca AB, Mölndal, Sweden

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  • Gerd Assmann,

    Affiliations: Leibniz—Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany, Institute for Clinical Chemistry and Laboratory Medicine, University Clinics Münster, Münster, Germany

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  • Gianni Tognoni,

    Affiliation: Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy

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  • Rory Collins,

    Affiliation: Clinical Trials Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom

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  • Anders Hamsten,

    Affiliation: Department of Medicine, Karolinska Institute, Stockholm, Sweden

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  • Hugh Watkins, on behalf of the PROCARDIS Consortium mail

    To whom correspondence should be addressed. E-mail: hugh.watkins@cardiov.ox.ac.uk

    Affiliation: Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

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  • Published: May 19, 2006
  • DOI: 10.1371/journal.pgen.0020072

About the Authors

Martin Farrall, John F Peden, Hugh Watkins
Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
Fiona R Green
School of Biomedical and Molecular Sciences, University of Surrey, Guildford, United Kingdom
Per G Olsson, Gunnar Olsson
AstraZeneca AB, Mölndal, Sweden
Robert Clarke, Rory Collins
Clinical Trials Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom
Mai-Lis Hellenius, Jacob Lagercrantz, Anders Hamsten
Department of Medicine, Karolinska Institute, Stockholm, Sweden
Stephan Rust, Helmut Schulte, Gerd Assmann
Leibniz—Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany
Maria Grazia Franzosi, Gianni Tognoni
Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
Alisoun Carey
Oxagen Limited, Abingdon, Oxfordshire, United Kingdom
Gerd Assmann
Institute for Clinical Chemistry and Laboratory Medicine, University Clinics Münster, Münster, Germany

Corresponding Author

Email: hugh.watkins@cardiov.ox.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MF, FRG, JFP, PGO, RC, MLH, SR, JL, MGF, HS, AC, GO, GA, GT, RC, AH, and HW conceived and designed the experiments. MF, JFP, RC, and HW analyzed the data. MF, PGO, RC, MLH, SR, JL, MGF, HS, AC, GO, GA, GT, RC, and AH contributed reagents/materials/analysis tools. MF, FRG, JFP, and HW wrote the paper.