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Research Article

DNA Methylation Supports Intrinsic Epigenetic Memory in Mammalian Cells

  • Yong-Qing Feng,

    Affiliation: Department of Medicine, Division of Hematology, and Department of Cell Biology, Albert Einstein College Of Medicine, Bronx, New York, New York, United States of America

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  • Romain Desprat,

    Affiliation: Department of Medicine, Division of Hematology, and Department of Cell Biology, Albert Einstein College Of Medicine, Bronx, New York, New York, United States of America

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  • Haiqing Fu,

    Affiliation: Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Emmanuel Olivier,

    Affiliation: Department of Medicine, Division of Hematology, and Department of Cell Biology, Albert Einstein College Of Medicine, Bronx, New York, New York, United States of America

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  • Chii Mei Lin,

    Affiliation: Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Amanda Lobell,

    Affiliation: Department of Medicine, Division of Hematology, and Department of Cell Biology, Albert Einstein College Of Medicine, Bronx, New York, New York, United States of America

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  • Shilpa N Gowda,

    Affiliation: Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Mirit I Aladjem,

    Affiliation: Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, United States of America

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  • Eric E Bouhassira mail

    To whom correspondence should be addressed. E-mail: bouhassi@aecom.yu.edu

    Affiliation: Department of Medicine, Division of Hematology, and Department of Cell Biology, Albert Einstein College Of Medicine, Bronx, New York, New York, United States of America

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  • Published: April 28, 2006
  • DOI: 10.1371/journal.pgen.0020065

About the Authors

Yong-Qing Feng, Romain Desprat, Emmanuel Olivier, Amanda Lobell, Eric E Bouhassira
Department of Medicine, Division of Hematology, and Department of Cell Biology, Albert Einstein College Of Medicine, Bronx, New York, New York, United States of America
Haiqing Fu, Chii Mei Lin, Shilpa N Gowda, Mirit I Aladjem
Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, United States of America

Corresponding Author

Email: bouhassi@aecom.yu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

YQF, RD, HF, EO, CML, AL, MIA, and EEB conceived and designed the experiments. YQF, RD, HF, EO, CML, AL, SNG, and MIA performed the experiments. YQF, RD, HF, EO, CML, AL, MIA, and EEB analyzed the data. MIA and EEB wrote the paper.