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Research Article

Chemical Genetics Reveals an RGS/G-Protein Role in the Action of a Compound

  • Kevin Fitzgerald,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Svetlana Tertyshnikova,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Lisa Moore,

    Affiliation: Exelixis Incorporated, South San Francisco, California, United States of America

    X
  • Lynn Bjerke,

    Affiliation: Exelixis Incorporated, South San Francisco, California, United States of America

    X
  • Ben Burley,

    Affiliation: Exelixis Incorporated, South San Francisco, California, United States of America

    X
  • Jian Cao,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Pamela Carroll,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Robert Choy,

    Affiliation: Exelixis Incorporated, South San Francisco, California, United States of America

    X
  • Steve Doberstein,

    Affiliation: Exelixis Incorporated, South San Francisco, California, United States of America

    X
  • Yves Dubaquie,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Yvonne Franke,

    Affiliation: Exelixis Incorporated, South San Francisco, California, United States of America

    X
  • Jenny Kopczynski,

    Affiliation: Exelixis Incorporated, South San Francisco, California, United States of America

    X
  • Hendrik Korswagen,

    Affiliation: Hubrecht Laboratory, Centre for Biomedical Genetics, Utrecht, Netherlands

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  • Stanley R Krystek Jr.,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Nicholas J Lodge,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Ronald Plasterk,

    Affiliation: Hubrecht Laboratory, Centre for Biomedical Genetics, Utrecht, Netherlands

    X
  • John Starrett,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Terry Stouch,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • George Thalody,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Honey Wayne,

    Affiliation: Exelixis Incorporated, South San Francisco, California, United States of America

    X
  • Alexander van der Linden,

    Affiliation: Hubrecht Laboratory, Centre for Biomedical Genetics, Utrecht, Netherlands

    X
  • Yongmei Zhang,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Stephen G Walker,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Mark Cockett,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Judi Wardwell-Swanson,

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Petra Ross-Macdonald mail,

    To whom correspondence should be addressed. E-mail: Petra.RossMacdonald@bms.com

    Affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America

    X
  • Rachel M Kindt

    Affiliation: Exelixis Incorporated, South San Francisco, California, United States of America

    X
  • Published: April 21, 2006
  • DOI: 10.1371/journal.pgen.0020057

About the Authors

Kevin Fitzgerald, Svetlana Tertyshnikova, Jian Cao, Pamela Carroll, Yves Dubaquie, Stanley R Krystek Jr., Nicholas J Lodge, John Starrett, Terry Stouch, George Thalody, Yongmei Zhang, Stephen G Walker, Mark Cockett, Judi Wardwell-Swanson, Petra Ross-Macdonald
Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey, United States of America
Lisa Moore, Lynn Bjerke, Ben Burley, Robert Choy, Steve Doberstein, Yvonne Franke, Jenny Kopczynski, Honey Wayne, Rachel M Kindt
Exelixis Incorporated, South San Francisco, California, United States of America
Hendrik Korswagen, Ronald Plasterk, Alexander van der Linden
Hubrecht Laboratory, Centre for Biomedical Genetics, Utrecht, Netherlands

Corresponding Author

Email: Petra.RossMacdonald@bms.com

Competing Interests

This research was funded by Bristol-Myers Squibb and Exelixis Incorporated.

Author Contributions

KF, ST, LM, JC, PC, RC, SD, JK, NJL, SGW, MC, JWS, PRM, and RMK conceived and designed the experiments. KF, ST, LM, LB, BB, JC, RC, YF, HW, YZ, SGW, JWS, and RMK performed the experiments. KF, ST, LM, PC, RC, JK, YZ, SGW, JWS, PRM, and RMK analyzed the data. ST, YD, HK, SRK, Jr., NJL, RP, JS, TS, GT, and AvdL contributed reagents/materials/analysis tools. KF, PRM, and RMK wrote the paper.