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Research Article

On the Mechanism of Gene Amplification Induced under Stress in Escherichia coli

  • Andrew Slack,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

    ¤ Current address: Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • P. C Thornton,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Daniel B Magner,

    Affiliation: Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Susan M Rosenberg,

    Affiliations: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America

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  • P. J Hastings mail

    To whom correspondence should be addressed. E-mail: hastings@bcm.tmc.edu

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Published: April 07, 2006
  • DOI: 10.1371/journal.pgen.0020048

About the Authors

Andrew Slack, P. C Thornton, Susan M Rosenberg, P. J Hastings
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
Daniel B Magner, Susan M Rosenberg
Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
Susan M Rosenberg
Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
Susan M Rosenberg
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America

Corresponding Author

Email: hastings@bcm.tmc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PJH conceived and designed the experiments. AS, PCT, and PJH performed the experiments. AS and PJH analyzed the data. DBM designed and constructed strains and genetic elements. SMR provided reagents and intellectual insights. AS, SMR, and PJH interpreted results. SMR and PJH wrote the paper.